{"product_id":"abcam-ab265824","title":"Abcam, ab265824, Human ERMP1 knockout HeLa cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nERMP1 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp insertion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HeLa,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Cervix,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Homozygous: 1 bp insertion in exon 1,\u003cbr\u003e\nDisease:Adenocarcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-ERMP1, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nERMP1 also known as Endoplasmic Reticulum Metallopeptidase 1 is a protein that plays an important role in cellular processes. The protein has a mass of approximately 127 kDa and is widely expressed in various tissues with higher expression levels in the pancreas liver and other organs with secretory functions. ERMP1 is located in the endoplasmic reticulum where it interfaces with cellular machinery involved in protein folding and processing.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nERMP1 regulates protein quality control within its cellular environment. By maintaining the integrity of protein synthesis it contributes to the proper functioning of the cellular proteome. ERMP1 is part of the endoplasmic reticulum quality control system ensuring proteins are properly folded and functional before they proceed to their destination. This protein works synergistically with other components of the cellular machinery to execute its functions effectively though it is not part of a specific protein complex.\u003cbr\u003e\nPathways\u003cbr\u003e\nERMP1 plays a significant role in the endoplasmic reticulum-associated degradation (ERAD) pathway which is essential for clearing misfolded proteins. It contributes to the ubiquitin-proteasome system interacting with proteins involved in tagging defective proteins for degradation. ERMP1 is connected to proteins such as ubiquitin ligases which are important for identifying and targeting proteins for degradation therefore ensuring cellular homeostasis and preventing stress.\u003cbr\u003e\nERMP1 has implications in neurodegenerative diseases and diabetes. Its ability to control protein folding and degradation is critical in these contexts. In neurodegenerative diseases such as Alzheimer's ERMP1 can influence the accumulation of misfolded proteins thereby impacting disease progression. Similarly in diabetes the disruption of ERMP1's function affects insulin production and secretion. In both cases the protein's interaction with insulin factor proteins and other signal molecules highlights its importance in disease outcomes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845208461481,"sku":"ab265824","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab265824","provider":"Iright","version":"1.0","type":"link"}