{"product_id":"abcam-ab266205","title":"Abcam, ab266205, Human ZNF593 knockout HEK-293T cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nZNF593 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Homozygous: 17 bp deletion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HEK-293T,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Kidney,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Homozygous: 17 bp deletion in exon 1\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-ZNF593, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nZNF593 also known as Zinc Finger Protein 593 is a protein with a mass of approximately 30 kDa. It functions as a transcriptional regulator modulating gene expression through binding DNA. ZNF593 is expressed mainly in the nucleus of cells with a concentration in tissues such as the liver kidney and heart. Its zinc finger motif suggests a role in DNA binding and regulatory functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nZNF593 is essential in managing the transcriptional activities within cells. It associates with a multiprotein complex interacting with other proteins to influence transcription. This protein plays a role in regulating cell proliferation and differentiation impacting how cells specialize and grow. Its involvement in interaction with RNA polymerase II highlights its role in gene expression regulation making it important in managing various cellular processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis protein enhances our understanding of cellular signaling and communication. ZNF593 is involved in the MAPK\/ERK and JAK\/STAT signaling pathways. These pathways control essential processes like cell growth differentiation and response to external stimuli. ZNF593 interacts directly with key proteins within these pathways such as ERK and STAT which further supports its role in modulating cell fate decisions and signaling cascades.\u003cbr\u003e\nZNF593's deregulation links to certain cancers and developmental disorders. Abnormal expression of ZNF593 correlates with progression in liver cancer where it impacts cell proliferation and survival. In addition mutations affecting ZNF593 have been associated with intellectual disabilities. Its interaction with proteins like STAT in these contexts underlines its pathological significance emphasizing the importance of proper regulation for maintaining cellular health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845196107945,"sku":"ab266205","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab266205","provider":"Iright","version":"1.0","type":"link"}