{"product_id":"abcam-ab266225","title":"Abcam, ab266225, Human LAMTOR4 knockout HEK-293T cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nLAMTOR4 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Homozygous: 4 bp deletion in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HEK-293T,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Kidney,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Homozygous: 4 bp deletion in exon 2\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-LAMTOR4, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLAMTOR4 also known as late endosomal\/lysosomal adaptor and MAPK and MTOR activator 4 is a component of the Ragulator complex. It interacts with specific proteins to anchor the Rag GTPases on lysosomal membranes. LAMTOR4 is a protein with a mass of approximately 11 kDa. Researchers have detected its expression primarily in cellular membranes especially within lysosomes positioning it as key in related processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein plays a role in nutrient sensing and cellular growth regulation. LAMTOR4 is part of the Ragulator complex a scaffolding complex essential for the activation of mTORC1 a central regulator of cell growth and metabolism. LAMTOR4 contributes to the recruitment and activation of mTORC1 at the lysosomal surface which is important for the integration of nutrient and energetic signals.\u003cbr\u003e\nPathways\u003cbr\u003e\nLAMTOR4 is involved in the mTOR signaling pathway closely related to cellular metabolism and growth. This protein interacts with other members of the Ragulator complex like LAMTOR1 and LAMTOR2 all connecting in the process of mTORC1 activation. Through the mTOR pathway LAMTOR4 modulates autophagy and anabolic processes therefore maintaining cellular homeostasis.\u003cbr\u003e\nAlterations in the function of LAMTOR4 have associations with metabolic disorders and cancerous conditions. The regulatory role of LAMTOR4 in mTORC1 activation links it to conditions such as tuberous sclerosis complex where mTOR signaling is disrupted. Alterations in LAMTOR4 and associated proteins like mTOR and other Ragulator complex members can contribute to pathogenesis by disrupting normal cellular growth and metabolism.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845079224489,"sku":"ab266225","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab266225","provider":"Iright","version":"1.0","type":"link"}