{"product_id":"abcam-ab266386","title":"Abcam, ab266386, Human ATRAID (C2orf28) knockout HEK-293T cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nATRAID KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Homozygous: 11 bp deletion in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HEK-293T,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Kidney,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Homozygous: 11 bp deletion in exon 2\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-ATRAID, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nC2orf28 also called FLJ20492 is a protein encoded by a gene on chromosome 2 open reading frame 28. This protein has a molecular mass of approximately 20 kDa. It is chiefly expressed in various human tissues including the brain heart and liver. Mechanically C2orf28 interacts with other cellular components although its precise role in cellular processes is not fully defined yet.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe C2orf28 protein contributes to intracellular signaling and regulatory processes. Although this protein is not widely recognized as part of a complex it participates in maintaining cellular homeostasis which involves a variety of regulatory functions. Due to its expression pattern and regulatory roles it is considered to have an impact at the cellular level.\u003cbr\u003e\nPathways\u003cbr\u003e\nC2orf28 engages in several cell signaling and metabolic pathways. It notably influences pathways related to cellular stress responses and metabolic regulation. The protein may interact with other mediators like AKT1 and MTOR which are essential in these pathways. C2orf28's involvement in such pathways underlines its role in modulating cellular dynamics.\u003cbr\u003e\nC2orf28 is linked with neurodegenerative conditions and metabolic disorders. Research indicates its potential involvement in Alzheimer's disease due to its expression in the brain and interaction with proteins like tau. Additionally its role in metabolic regulation suggests a connection to disorders such as diabetes where it may interact with proteins involved in insulin signaling. Further studies could elucidate the precise mechanisms of these associations.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845207511209,"sku":"ab266386","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab266386","provider":"Iright","version":"1.0","type":"link"}