{"product_id":"abcam-ab266660","title":"Abcam, ab266660, Human WDR83OS (C19orf56) knockout HEK-293T cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nWDR83OS KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 7 bp deletion in exon 1 and 8 bp deletion in exon 1. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HEK-293T,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Kidney,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 7 bp deletion in exon 1 and 8 bp deletion in exon 1\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-WDR83OS, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nC19orf56 also known as MONA or INIP functions as an important player in DNA repair processes specifically homologous recombination. It has a molecular weight of approximately 26 kDa. This protein shows expression across various tissues but appears more prominently in the testis and thymus. As part of DNA repair machinery C19orf56 participates in maintaining genome stability by facilitating accurate DNA exchange during cell division.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe maintenance of genome integrity involves the activity of C19orf56. C19orf56 operates within the DNA damage response and associates with other components to form repair complexes. It is necessary for effective repair of double-strand breaks which protects cells from accumulating mutations. The protein acts in coordination with diverse repair enzymes and structural proteins to detect and correct DNA damage ensuring genomic stasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nC19orf56 serves an essential role in the homologous recombination repair pathway. It interacts closely with proteins like RAD51 an important partner within this pathway. The protein also contributes to the DNA damage signaling pathway where it may interact with p53 an important regulator of the cell cycle and apoptosis. This shows the protein's function in important cellular mechanisms governing cell division and stability.\u003cbr\u003e\nC19orf56 shows connections to conditions like cancer and Fanconi anemia. Alterations in its function can lead to genomic instability increasing cancer susceptibility. Its interaction with BRCA1 indicates a potential impact on breast cancer pathology where ineffective repair pathways may facilitate oncogenic transformations. Also defects in C19orf56 have associations with impaired bone marrow function seen in Fanconi anemia linking the protein to hematopoietic disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845148889257,"sku":"ab266660","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab266660","provider":"Iright","version":"1.0","type":"link"}