{"product_id":"abcam-ab266845","title":"Abcam, ab266845, Human TAB1 knockout HEK-293T cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nTAB1 KO cell line available to order. KO validated by Western blot. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, Homozygous: 20 bp deletion in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:HEK-293T,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Kidney,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,Western blot,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, Homozygous: 20 bp deletion in exon 2\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-TAB1, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Western blot, Zygosity-Homozygous, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTAB1 also known as TGF-beta-activated kinase 1 binding protein 1 is a protein involved in signal transduction processes. It has a mass of approximately 68 kDa. TAB1 is expressed in various human tissues with notable presence in immune cells such as macrophages and lymphocytes. Mechanically TAB1 acts as a regulatory molecule that binds to and activates TAK1 an important kinase involved in several signaling cascades. This interaction facilitates the phosphorylation events necessary for downstream signal propagation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTAB1 functions as a scaffold protein assisting in the assembly of signaling complexes. This protein is part of the TAK1 complex which also includes TAB2 and TAB3. The formation of this complex is essential for activating multiple intracellular signaling pathways. Through its role in the TAK1 complex TAB1 contributes to cellular responses to environmental cues including inflammation apoptosis and immune responses. Its activity influences transcription factor activation and is pivotal in orchestrating cellular adaptation to changes.\u003cbr\u003e\nPathways\u003cbr\u003e\nTAB1 is essential in both the NF-kB and MAPK signaling pathways. Maintaining proper function in these pathways is important for inflammatory responses and stress-related signal transduction. TAB1 helps bridge the activation of TAK1 to the downstream signaling required for NF-kB pathway activation. Additionally in the MAPK pathway TAB1 influences the activation of proteins such as MKKs which further regulate cellular stress responses and developmental processes.\u003cbr\u003e\nTAB1 plays a role in inflammatory diseases and cancer. Dysregulation of TAB1 activity can result in chronic inflammation contributing to conditions like rheumatoid arthritis. In cancer altered TAB1 expression or function can lead to unchecked cell growth and survival. TAB1 connects to other proteins such as TAK1 in these diseases as it modulates signaling pathways that determine cellular fate. Understanding TAB1's involvement in these disorders opens potential therapeutic avenues targeting its interactions and function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845064216745,"sku":"ab266845","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab266845","provider":"Iright","version":"1.0","type":"link"}