{"product_id":"abcam-ab266910","title":"Abcam, ab266910, Human THEMIS2 (ICB1) knockout A549 cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nTHEMIS2 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 1 bp deletion in exon 2 and 1 bp insertion in exon 2. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:A549,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Lung,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 1 bp deletion in exon 2 and 1 bp insertion in exon 2,\u003cbr\u003e\nDisease:Carcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute, ERS Genomics Limited and Sigma-Aldrich Co. LLC, and is developed with patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-THEMIS2, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein ICB1 also known as Intermediate Complex B1 exhibits mechanical functions critical to cellular processes. With a molecular mass of approximately 50 kDa ICB1 is widely expressed in various tissues including the liver brain and muscles. This protein contributes to important mechanistic roles in cells influencing their structural and functional stability. Its distribution across different tissues indicates its involvement in diverse cellular functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of ICB1 is linked to cellular signaling pathways and structural maintenance. It often forms part of a larger protein complex within the cytoplasm contributing to cytoskeletal integrity. Through its interactions ICB1 helps in the regulation of intracellular transport and communication. Its integration into multiprotein complexes highlights its importance in maintaining cellular architecture and communication networks.\u003cbr\u003e\nPathways\u003cbr\u003e\nICB1 participates in signaling cascades such as the MAPK and PI3K-Akt pathways. These pathways are essential for cell survival growth and differentiation. ICB1 interacts with proteins like Akt and ERK1\/2 helping to mediate signals that influence cell fate decisions. Its role in these pathways highlights its importance in regulating cell proliferation and responses to external stimuli.\u003cbr\u003e\nICB1 has connections to neurodegenerative diseases and certain cancers. In Alzheimer's disease ICB1 is thought to influence the pathology through its interaction with tau proteins contributing to neurofibrillary tangle formation. In some types of cancer alterations in ICB1 expression affect cell cycle regulation promoting unrestrained growth. Understanding the involvement of ICB1 with proteins like tau and cyclin-dependent kinases in these contexts is important for therapeutic development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845165863081,"sku":"ab266910","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab266910","provider":"Iright","version":"1.0","type":"link"}