{"product_id":"abcam-ab267141","title":"Abcam, ab267141, Human ANGPTL6 knockout A549 cell line","description":"\u003cp\u003eSize: 2 x 1000000Cells \/ vial \/ 1000000Cells \/ vial\u003cbr\u003e\nANGPTL6 KO cell line available to order. KO validated by. Free of charge wild type control available. Knockout achieved by using CRISPR\/Cas9, 4 bp deletion in exon 3 and 5 bp deletion in exon 3. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:A549,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Lung,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Sanger Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by using CRISPR\/Cas9, 4 bp deletion in exon 3 and 5 bp deletion in exon 3,\u003cbr\u003e\nDisease:Carcinoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-ANGPTL6, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Sanger Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nANGPTL6 also known as Angiopoietin-like 6 is a protein involved in modulating several physiological processes. The protein has a molecular weight of approximately 54 kDa. ANGPTL6 is expressed in various tissues such as the liver heart and adipose tissue indicating its involvement in systemic functions. The protein is a secretory glycoprotein influencing various cellular mechanisms due to its diverse localization.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nANGPTL6 functions in the regulation of metabolic processes including glucose and lipid metabolism. It is not part of a larger complex but acts individually in its biological roles. ANGPTL6 has been shown to improve insulin sensitivity and promote energy expenditure. Through these mechanisms it plays an essential role in maintaining metabolic homeostasis and supports cellular health.\u003cbr\u003e\nPathways\u003cbr\u003e\nANGPTL6 significantly interacts within metabolic and cardiovascular pathways. The protein influences the insulin signaling pathway and is connected to proteins like AKT and PI3K integral components of metabolic regulation. ANGPTL6 also affects pathways involved in angiogenesis providing cross-talk with vascular endothelial growth factor (VEGF)-mediated signaling an important aspect of cardiovascular health.\u003cbr\u003e\nANGPTL6 has connections to metabolic syndrome and obesity-related conditions. Its role in maintaining insulin sensitivity and influencing glucose metabolism links it to type 2 diabetes. By modulating pathways related to lipid balance ANGPTL6 also relates to cardiovascular diseases. Associations with proteins such as VEGF and AKT elucidate its involvement in vascular health and metabolic disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845135454377,"sku":"ab267141","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab267141","provider":"Iright","version":"1.0","type":"link"}