{"product_id":"abcam-ab267355","title":"Abcam, ab267355, Anti-HHV8 antibody [HHV8\/3606] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal HHV8 antibody. Carrier free. Suitable for IHC-P and reacts with Human gammaherpesvirus 8 samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:HHV8\/3606,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human gammaherpesvirus 8,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab267355 is the carrier-free version of\u003cbr\u003e\nab267354\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A\/G, Purification notes-Purified from bioreactor concentrate., Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHHV-8 also known as Human Herpesvirus 8 or Kaposi's Sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA virus with a genome mass of approximately 165 kilobase pairs. It mainly expresses in endothelial cells B lymphocytes and epithelial cells. The virus encodes several proteins that mimic host cell proteins influencing cell regulation and survival. One well-documented tool for detection includes HHV-8 immunostain techniques which assist in identifying viral presence in tissues. Important markers such as LN53 are often used in conjunction with HHV-8 IHC (immunohistochemistry) to facilitate accurate identification and study of this virus's expressions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHHV-8 disrupts normal cellular processes by expressing proteins like LANA (latency-associated nuclear antigen) that interfere with host cellular mechanisms. It is known to be part of complex interactions within infected cells chiefly affecting the tumor suppressor pathways. These proteins lead to changes that permit the infected cells to escape immune destruction and continue proliferating unchecked. Despite interventions the virus maintains a dormant state in the host which makes complete eradication difficult.\u003cbr\u003e\nPathways\u003cbr\u003e\nHHV-8 influences two major biological pathways—the p53 signaling pathway and the NF-kB signaling pathway. The virus's interference with the p53 protein which plays a critical role in controlling cell cycle arrest and apoptosis is a major aspect of its pathogenic capacity. Additionally HHV-8 can activate the NF-kB pathway which leads to inflammation and survival signaling encouraging oncogenic transformation. This viral manipulation disrupts normal cellular homeostasis and contributes to disease manifestation.\u003cbr\u003e\nHHV-8 is strongly associated with Kaposi's sarcoma a vascular tumor affecting the skin and other tissues and primary effusion lymphoma. These diseases are connected to the virus through its interactions with host cellular proteins like p53 and the aforementioned pathways. The LANA protein is significant in Kaposi’s sarcoma pathogenesis by binding to p53 and RB protein inhibiting their tumor suppressor functions. Furthermore HHV-8’s ability to remain latent and resist host immune controls complicates treatment and highlights the importance of understanding its role in disease development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854526042281,"sku":"ab267355","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab267355","provider":"Iright","version":"1.0","type":"link"}