{"product_id":"abcam-ab268380","title":"Abcam, ab268380, Recombinant human CAMKK2 protein (Active)","description":"\u003cp\u003eSize: 5µg\u003cbr\u003e\nRecombinant human CAMKK2 protein (Active) is a Human Full Length protein, expressed in Baculovirus infected Sf9 cells, with \u0026gt;70%, suitable for SDS-PAGE, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;70% SDS-PAGE,\u003cbr\u003e\nExpression system:Baculovirus infected Sf9 cells,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:The specific activity of ab268380 was 2.1 nmol\/min\/mg in a kinase assay using myelin basic protein as substrate.,\u003cbr\u003e\nAccession:Q96RR4,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, 0.79% Tris HCl, 0.31% Glutathione, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCalcium\/calmodulin-dependent protein kinase kinase 2 (CAMKK2) also known as CAMK or CAMKK-beta is an important protein kinase. It has a mass of approximately 66 kDa and is mainly expressed in the brain but also found in other tissues such as the liver and pancreas. CAMKK2 functions as an upstream kinase activating downstream kinases including CAMK1 and CAMK4. Through these interactions CAMKK2 plays an integral role in various cellular processes such as calcium signaling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCalcium\/calmodulin-dependent protein kinase kinase 2 influences neuronal function through its regulation of calcium signaling pathways. CAMKK2 participates in the formation of a complex with calmodulin when calcium levels rise. This interaction modulates neurotransmitter release neuronal growth and synaptic plasticity. Beyond the nervous system CAMKK2 contributes to metabolic processes in the liver and insulin secretion in the pancreas thereby affecting whole-body energy homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nCalcium\/calmodulin-dependent protein kinase kinase 2 is involved in the calcium signaling and AMP-activated protein kinase (AMPK) pathways. In these pathways CAMKK2 interacts with CAMK1 CAMK4 and AMPK influencing cellular activities like energy balance and apoptosis. The activation of AMPK by CAMKK2 plays a significant role in maintaining cellular energy levels by regulating glucose and lipid metabolism linking it to diverse physiological functions.\u003cbr\u003e\nDysregulation of calcium\/calmodulin-dependent protein kinase kinase 2 has connections to metabolic diseases and neurodegenerative disorders such as type 2 diabetes and Alzheimer's disease. Aberrant CAMKK2 activity can alter insulin signaling and energy homeostasis contributing to the development of type 2 diabetes. Additionally its interaction with calmodulin and downstream kinases may influence tau phosphorylation an important process in Alzheimer's pathology further illustrating the importance of CAMKK2 in disease contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843921137833,"sku":"ab268380","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab268380","provider":"Iright","version":"1.0","type":"link"}