{"product_id":"abcam-ab268698","title":"Abcam, ab268698, Recombinant human KAT7 \/ Hbo1 \/ MYST2 protein (Active)","description":"\u003cp\u003eSize: 5µg\u003cbr\u003e\nRecombinant human KAT7 \/ Hbo1 \/ MYST2 protein (Active) is a Human Full Length protein, in the 1 to 611 aa range, expressed in Baculovirus infected Sf9 cells, with \u0026gt;75%, suitable for SDS-PAGE, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;75% SDS-PAGE,\u003cbr\u003e\nExpression system:Baculovirus infected Sf9 cells,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:The specific activity of ab268698 was 0.4 nmol\/min\/mg in a acetyltransferase assay using histone H1 protein as substrate.,\u003cbr\u003e\nAccession:O95251,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 0.79% Tris HCl, 0.31% Glutathione, 0.29% Sodium chloride, 0.004% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.003% EDTA, 0.002% PMSF\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKAT7 also known as Hbo1 KAT-7 MYST2 KAT-7 and Katset functions as a histone acetyltransferase specifically modifying histone H4 at lysine 12 5 and 8. With a molecular mass typically around 63 kDa KAT7 is expressed in nucleus and localizes to chromatin. It associates with chromatin during DNA replication and is vital in histone H4 acetylation facilitating chromatin remodeling and gene expression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein plays a significant role in transcription regulation and DNA replication. KAT7 is a component of the HBO1 complex working together with other proteins like JADE1\/2\/3 BRPF1\/2\/3 and ING4\/5 making it integral to cell cycle progression and transcriptional activation. This complex is essential for initiating DNA replication as it acetylates histones and regulates chromatin accessibility necessary for DNA synthesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nKAT7\/Hbo1\/MYST2 is actively engaged in the transcriptional regulatory network and DNA replication pathways. It influences gene expression through its interaction with the transcriptional machinery and by modifying the chromatin structure. Within these pathways it interacts with proteins like BRPF1 and ING5 enhancing transcription and replication. This positions KAT7 as an important component in ensuring cellular growth and division through its histone acetylation activities.\u003cbr\u003e\nResearch indicates a link between KAT7 function and cancer. Its dysregulation contributes to tumorigenesis related to its role in cell proliferation and gene expression. KAT7 affects the expression of oncogenes and interacts with proteins like p53. Altered KAT7 activity disrupts normal cellular processes and in cancer results in aberrant cell cycle regulation and uncontrolled cell proliferation highlighting its potential as a therapeutic target in oncology.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843987591337,"sku":"ab268698","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab268698","provider":"Iright","version":"1.0","type":"link"}