{"product_id":"abcam-ab269817","title":"Abcam, ab269817, EI1, EZH2 inhibitor","description":"\u003cp\u003eSize: 10mg \/ 25mg \/ 50mg \/ 100mg\u003cbr\u003e\nMW 390.5 Da. Potent (IC 50  = 15 nM for wild-type enzyme; 13 nM for Y641F mutant enzyme) EZH2 inhibitor. Selective versus EZH1 (142-fold). Highly selective (\u0026gt;10,000-fold) against a panel of 10 other human methyltransferases. Inhibits cellular H3K27 methylation and activates Ezh2 target gene p16 expression in diffuse large B-cell lymphoma cells (DLBLC). Selectively inhibits growth and promotes cell cycle arrest and apoptosis of DLBLC cells with Y641 EZH2 mutations.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1418308-27-6,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:390.5 Da,\u003cbr\u003e\nMolecular formula:C23H26N4O2,\u003cbr\u003e\nPubChem:72199293,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 50 mM,\u003cbr\u003e\nBiochemical name:6-cyano-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-pentan-3-ylindole-4-carboxamide,\u003cbr\u003e\nBiological description:Potent (IC50 = 15 nM for wild-type enzyme; 13 nM for Y641F mutant enzyme) EZH2 inhibitor. Selective versus EZH1 (142-fold). Highly selective (\u0026gt;10,000-fold) against a panel of 10 other human methyltransferases. Inhibits cellular H3K27 methylation and activates Ezh2 target gene p16 expression in diffuse large B-cell lymphoma cells (DLBLC). Selectively inhibits growth and promotes cell cycle arrest and apoptosis of DLBLC cells with Y641 EZH2 mutations.,\u003cbr\u003e\nCanonical smiles:CCC(CC)N1C=CC2=C(C=C(C=C21)C#N)C(=O)NCC3=C(C=C(NC3=O)C)C,\u003cbr\u003e\nInChi:InChI=1S\/C23H26N4O2\/c1-5-17(6-2)27-8-7-18-19(10-16(12-24)11-21(18)27)22(28)25-13-20-14(3)9-15(4)26-23(20)29\/h7-11,17H,5-6,13H2,1-4H3,(H,25,28)(H,26,29),\u003cbr\u003e\nInChiKey:PFHDWRIVDDIFRP-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:6-cyano-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-pentan-3-ylindole-4-carboxamide\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847474466985,"sku":"ab269817","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab269817","provider":"Iright","version":"1.0","type":"link"}