{"product_id":"abcam-ab269876","title":"Abcam, ab269876, Sonidegib (NVP-LDE225, Erismodegib), smoothened (Smo) antagonist","description":"\u003cp\u003eSize: 10mg \/ 50mg \/ 100mg\u003cbr\u003e\nMW 485.5 Da. Potent and selective Smoothened antagonist. Blocks Hedgehog signaling pathway activity (IC 50  = 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays. Anti-tumor activity in mouse medulloblastoma allograft model.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:956697-53-3,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:485.5 Da,\u003cbr\u003e\nMolecular formula:C26H26F3N3O3,\u003cbr\u003e\nPubChem:24775005,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 50 mM,\u003cbr\u003e\nBiochemical name:Sonidegib,\u003cbr\u003e\nBiological description:Potent and selective Smoothened antagonist. Blocks Hedgehog signaling pathway activity (IC50 = 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays. Anti-tumor activity in mouse medulloblastoma allograft model.,\u003cbr\u003e\nCanonical smiles:CC1CN(CC(O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F,\u003cbr\u003e\nIsomeric smiles:C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F,\u003cbr\u003e\nInChi:InChI=1S\/C26H26F3N3O3\/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29\/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)\/t16-,17+,\u003cbr\u003e\nInChiKey:VZZJRYRQSPEMTK-CALCHBBNSA-N,\u003cbr\u003e\nIUPAC Name:N-[6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]pyridin-3-yl]-2-methyl-3-[4-(trifluoromethoxy)phenyl]benzamide\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847478399145,"sku":"ab269876","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab269876","provider":"Iright","version":"1.0","type":"link"}