{"product_id":"abcam-ab271680","title":"Abcam, ab271680, Recombinant human PDE4B3 protein (Active)","description":"\u003cp\u003eSize: 5µg\u003cbr\u003e\nRecombinant human PDE4B3 protein (Active) is a Human Full Length protein, in the 2 to 721 aa range, expressed in Baculovirus infected Sf9 cells, with \u0026gt;90%, suitable for SDS-PAGE, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% SDS-PAGE,\u003cbr\u003e\nExpression system:Baculovirus infected Sf9 cells,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:Specific Activity: 10,500 pmole\/min\/μg.One unit is defined as the amount of enzyme that will convert 1 pmole of 3′, 5′-cAMP to 5′-AMP per min at 37°C.,\u003cbr\u003e\nAccession:Q07343,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 8Constituents: 20% Glycerol (glycerin, glycerine), 0.64% Sodium chloride, 0.63% Tris HCl, 0.05% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.04% Sorbitan monolaurate, ethoxylated, 0.02% Potassium chloride\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPDE4B3 also known as phosphodiesterase 4B3 is an isoform of the PDE4B enzyme. This enzyme has a mass of approximately 80 kDa. PDE4B3 regulates intracellular levels of cyclic AMP (cAMP) by hydrolyzing cAMP to 5’-AMP therefore controlling signaling pathways that depend on this second messenger. PDE4B3 expression occurs mainly in cells of the immune system especially in leukocytes as well as in the brain.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe activity of PDE4B3 modulates immune responses and central nervous system functions by determining the concentration of cAMP. PDE4B3 is part of a larger family of phosphodiesterases that degrade cAMP. This regulation of cAMP influences important cellular processes such as gene expression and inflammatory responses highlighting its role within complex signaling networks that maintain cellular homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nPDE4B3 plays a critical role in signaling pathways like the cAMP-dependent signaling pathway. It directly interacts with proteins involved in these pathways such as protein kinase A (PKA) to control downstream effects related to inflammation and neurotransmission. PDE4B3's degradation of cAMP serves as a negative feedback mechanism in these pathways. It shares functional similarities with other PDE4 family members but its distinct expression pattern provides its unique contributions to these pathways.\u003cbr\u003e\nPDE4B3 has been implicated in several conditions including depression and chronic obstructive pulmonary disease (COPD). Studies link altered PDE4B3 activity to dysregulation of cAMP metabolism which affects inflammatory processes and neurotransmitter release associated with these diseases. Additionally its interaction with proteins such as PKA highlights potential therapeutic targets for modulating PDE4B3 activity in these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843931132073,"sku":"ab271680","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab271680","provider":"Iright","version":"1.0","type":"link"}