{"product_id":"abcam-ab272716","title":"Abcam, ab272716, Anti-Galectin 13\/PLAC8 + Galectin-16 antibody [EPR23383-89]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal LEG16 antibody. Suitable for IP, WB, IHC-P and reacts with Human, Recombinant fragment - Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR23383-89,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb\u003cbr\u003e\npatents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGalectin 13 also known as PLAC8 or Galectin-16 is a type of protein that belongs to the Galectin family. It functions by binding to β-galactoside sugars which allows it to interact with glycoproteins and cell surfaces. The protein has a mass of approximately 16 kDa. Expression occurs mainly in the placenta suggesting a role in reproductive physiology but it has also been identified in other tissues to lesser extents including the colon.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGalectin 13\/PLAC8 Galectin-16 plays significant roles in modulating immune responses and cell-cell interactions. It appears integral to the maintenance of an immune-tolerant environment particularly in the placenta supporting successful implantation and pregnancy. The protein might operate as part of a complex involving other members of the Galectin family to regulate immune checkpoints and enhance cell adhesion processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nGalectin 13\/PLAC8 Galectin-16 contributes to essential biological pathways linked to cell signaling and immune system modulation. It influences the JAK\/STAT signaling pathway which is vital for cell proliferation and differentiation modes. This involvement supports balanced communication within immune responses and the protein interacts with other Galectins and perhaps other signaling molecules within this context.\u003cbr\u003e\nAlterations in Galectin 13\/PLAC8 Galectin-16 levels have associations with preeclampsia a complex pregnancy disorder marked by hypertension and organ dysfunction. Studies illustrating its role show connections to inflammatory conditions that might affect pregnancy outcomes. Its interactions with other proteins such as Galectin-1 highlight potential mechanisms in placental pathophysiology and broader implications in immune-mediated disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855883522217,"sku":"ab272716","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab272716","provider":"Iright","version":"1.0","type":"link"}