{"product_id":"abcam-ab273432","title":"Abcam, ab273432, GSK1904529A","description":"\u003cp\u003eSize: 10mg \/ 50mg\u003cbr\u003e\nMW 852 Da, Purity \u0026gt;98%. Selective IGF-1R (IC 50  = 27 nM in cell) and Insulin Receptor (IC 50  = 25 nM) tyrosine kinase inhibitor in cell-free assays. Reversible, ATP-competitive (Ki = 1.6 nM). Blocks ligand induced autophosphorylation of IGF-1R and IR and activation of downstream Akt, IRS-1 and ERK signaling pathways. Inhibits proliferation of various cell lines. Induces G1 cell cycle arrest.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1089283-49-7,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:852 Da,\u003cbr\u003e\nMolecular formula:C44H47F2N9O5S,\u003cbr\u003e\nPubChem:25124816,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 50 mM,\u003cbr\u003e\nBiochemical name:N-(2,6-difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonyl-1-piperazinyl)-1-piperidinyl]anilino]-4-pyrimidinyl]-2-imidazo[1,2-a]pyridinyl]-2-methoxybenzamide,\u003cbr\u003e\nBiological description:Selective IGF-1R (IC50 = 27 nM in cell) and Insulin Receptor (IC50 = 25 nM) tyrosine kinase inhibitor in cell-free assays. Reversible, ATP-competitive (Ki = 1.6 nM). Blocks ligand induced autophosphorylation of IGF-1R and IR and activation of downstream Akt, IRS-1 and ERK signaling pathways. Inhibits proliferation of various cell lines. Induces G1 cell cycle arrest.,\u003cbr\u003e\nCanonical smiles:CCC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)S(=O)(=O)C)OC)NC4=NC=CC(=N4)C5=C(N=C6N5C=CC=C6)C7=CC(=C(C=C7)OC)C(=O)NC8=C(C=CC=C8F)F,\u003cbr\u003e\nInChi:InChI=1S\/C44H47F2N9O5S\/c1-5-28-26-35(38(60-3)27-36(28)53-19-15-30(16-20-53)52-21-23-54(24-22-52)61(4,57)58)49-44-47-17-14-34(48-44)42-40(50-39-11-6-7-18-55(39)42)29-12-13-37(59-2)31(25-29)43(56)51-41-32(45)9-8-10-33(41)46\/h6-14,17-18,25-27,30H,5,15-16,19-24H2,1-4H3,(H,51,56)(H,47,48,49),\u003cbr\u003e\nInChiKey:MOSKATHMXWSZTQ-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:N-(2,6-difluorophenyl)-5-[3-[2-[5-ethyl-2-methoxy-4-[4-(4-methylsulfonylpiperazin-1-yl)piperidin-1-yl]anilino]pyrimidin-4-yl]imidazo[1,2-a]pyridin-2-yl]-2-methoxybenzamide\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847485182121,"sku":"ab273432","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab273432","provider":"Iright","version":"1.0","type":"link"}