{"product_id":"abcam-ab273489","title":"Abcam, ab273489, GDC0879","description":"\u003cp\u003eSize: 5mg \/ 25mg \/ 100mg\u003cbr\u003e\nMW 334.4 Da, Purity \u0026gt;98%. Potent and selective B-Raf inhibitor (IC 50  = 0.13 nM against purified V600E enzyme). Inhibits cellular pERK (IC 50  = 63 nM). Blocks Raf\/MEK\/ERK signaling in B-Raf V600E mutant cell lines. Highly selective against a panel of 140 full-length protein kinases.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:905281-76-7,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:334.4 Da,\u003cbr\u003e\nMolecular formula:C19H18N4O2,\u003cbr\u003e\nPubChem:11717001,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 50 mM,\u003cbr\u003e\nBiochemical name:(E)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime,\u003cbr\u003e\nBiological description:Potent and selective B-Raf inhibitor (IC50 = 0.13 nM against purified V600E enzyme). Inhibits cellular pERK (IC50 = 63 nM). Blocks Raf\/MEK\/ERK signaling in B-Raf V600E mutant cell lines. Highly selective against a panel of 140 full-length protein kinases.,\u003cbr\u003e\nCanonical smiles:C1CC(=NO)C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO,\u003cbr\u003e\nIsomeric smiles:C1C\/C(=N\\O)\/C2=C1C=C(C=C2)C3=CN(N=C3C4=CC=NC=C4)CCO,\u003cbr\u003e\nInChi:InChI=1S\/C19H18N4O2\/c24-10-9-23-12-17(19(21-23)13-5-7-20-8-6-13)15-1-3-16-14(11-15)2-4-18(16)22-25\/h1,3,5-8,11-12,24-25H,2,4,9-10H2\/b22-18+,\u003cbr\u003e\nInChiKey:DEZZLWQELQORIU-RELWKKBWSA-N,\u003cbr\u003e\nIUPAC Name:2-[4-[(1E)-1-hydroxyimino-2,3-dihydroinden-5-yl]-3-pyridin-4-ylpyrazol-1-yl]ethanol\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nFor obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20°C for several months.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847492358313,"sku":"ab273489","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab273489","provider":"Iright","version":"1.0","type":"link"}