{"product_id":"abcam-ab273602","title":"Abcam, ab273602, Belnacasan (VX-765)","description":"\u003cp\u003eSize: 5mg \/ 25mg\u003cbr\u003e\nMW 509 Da, Purity \u0026gt;98%. Potent and selective inhibitor against caspase-1 with Ki of 0.8 nM. Orally absorbed. Also inhibits IL-1β release from both PBMCs and whole blood with IC50 of 0.67 μM and 1.9 μM,  in vitro . Inhibits LPS-induced IL-1β production in collagen-induced arthritis mouse model,  in vivo .\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:273404-37-8,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:509 Da,\u003cbr\u003e\nMolecular formula:C24H33ClN4O6,\u003cbr\u003e\nPubChem:11398092,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to 50 mMSoluble in ethanol to 50 mM,\u003cbr\u003e\nBiochemical name:Belnacasan,\u003cbr\u003e\nBiological description:Potent and selective inhibitor against caspase-1 with Ki of 0.8 nM. Orally absorbed. Also inhibits IL-1β release from both PBMCs and whole blood with IC50 of 0.67 μM and 1.9 μM, in vitro. Inhibits LPS-induced IL-1β production in collagen-induced arthritis mouse model, in vivo.,\u003cbr\u003e\nCanonical smiles:CCOC1C(CC(=O)O1)NC(=O)C2CCCN2C(=O)C(C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl,\u003cbr\u003e\nIsomeric smiles:CCO[C@H]1[C@H](CC(=O)O1)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C(C)(C)C)NC(=O)C3=CC(=C(C=C3)N)Cl,\u003cbr\u003e\nInChi:InChI=1S\/C24H33ClN4O6\/c1-5-34-23-16(12-18(30)35-23)27-21(32)17-7-6-10-29(17)22(33)19(24(2,3)4)28-20(31)13-8-9-15(26)14(25)11-13\/h8-9,11,16-17,19,23H,5-7,10,12,26H2,1-4H3,(H,27,32)(H,28,31)\/t16-,17-,19+,23+\/m0\/s1,\u003cbr\u003e\nInChiKey:SJDDOCKBXFJEJB-MOKWFATOSA-N,\u003cbr\u003e\nIUPAC Name:(2S)-1-[(2S)-2-[(4-amino-3-chlorobenzoyl)amino]-3,3-dimethylbutanoyl]-N-[(2R,3S)-2-ethoxy-5-oxooxolan-3-yl]pyrrolidine-2-carboxamide\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847454707881,"sku":"ab273602","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab273602","provider":"Iright","version":"1.0","type":"link"}