{"product_id":"abcam-ab273674","title":"Abcam, ab273674, Anti-LAT2 antibody [UMAB70] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal LAT2 antibody. Carrier free. Suitable for Protein Microarray ChIP, IHC-P, WB, ICC\/IF and reacts with Purified native protein - Human, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human SLC7A8.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:UMAB70,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WB, IHC-P, Protein Microarray ChIPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human SLC7A8.Q9UHI5\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A\/G, Purification notes-Purified from TCS., Storage buffer-pH: 7.3Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLAT2 also known as Linker for Activation of T cells 2 is a cytoplasmic adaptor protein with a molecular mass of approximately 38 kDa. LAT2 plays an important role in intracellular signaling and is widely expressed in immune system cells especially T cells mast cells and platelets. This protein functions as a scaffold providing binding sites for several signaling molecules involved in immune cell activation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLAT2 contributes significantly to immune system responses. It forms complexes with proteins such as SLP-76 to facilitate signal transduction. LAT2 becomes phosphorylated upon activation which recruits multiple effector molecules and serves as a platform for further signaling processes. This mechanism enhances the transmission of activation signals that lead to immune cell proliferation and differentiation.\u003cbr\u003e\nPathways\u003cbr\u003e\nProteins interacting with LAT2 participate in the T cell receptor (TCR) signaling pathway and FcεRI signaling in mast cells. LAT2 anchors important signaling molecules within these pathways including ZAP-70 and PLCγ1 which further propagate the signal cascade necessary for immune responses. The LAT2-SLP-76 complex helps coordinate the assembly of various intracellular signaling proteins in these pathways which is vital for effective cellular functions.\u003cbr\u003e\nDefects or alterations in LAT2 function can result in immune system-related conditions such as immunodeficiencies and autoimmune disorders. Abnormal LAT2 signaling is linked to diseases like systemic lupus erythematosus where T cell signaling becomes dysregulated. Further LAT2 interacts with proteins such as Syk involved in other immune disorders highlighting its importance in maintaining immune system balance.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854601277609,"sku":"ab273674","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab273674","provider":"Iright","version":"1.0","type":"link"}