{"product_id":"abcam-ab277179","title":"Abcam, ab277179, Human GPR137 knockout U-2 OS cell line","description":"\u003cp\u003eSize: 1000000Cells \/ vial \/ 2 x 1000000Cells \/ vial\u003cbr\u003e\nGPR137 KO cell line available to order. KO validated by Next Generation Sequencing. Free of charge wild type control available. Knockout achieved by CRISPR\/Cas9 X = 1 bp deletion Frameshift: 100%. To order both knockout and wild-type control cells: select 2 x 1000000Cells\/vial. To order only knockout cells: select 1000000Cells\/vial.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCell type:U-2 OS,\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nTissue:Bone,\u003cbr\u003e\nForm:LiquidSee storage information,\u003cbr\u003e\nKnockout validation:Next Generation Sequencing,\u003cbr\u003e\nMutation description:Knockout achieved by CRISPR\/Cas9 X = 1 bp deletion Frameshift: 100%,\u003cbr\u003e\nDisease:Osteosarcoma\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWe will provide viable cells that proliferate on revival.\u003cbr\u003e\nThis product is subject to limited use licenses from The Broad Institute and ERS Genomics Limited, and is developed with patented technology. For full details of the limited use licenses and relevant patents please refer to our\u003cbr\u003e\nlimited use license\u003cbr\u003e\npatent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nGene name-GPR137, Gene editing type-Knockout, Gene editing method-CRISPR technology, Knockout validation-Next Generation Sequencing, Shipped at conditions-Dry Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions--196°C, -80°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGPR137 also known as G protein-coupled receptor 137 is a transmembrane protein with a mass of approximately 36 kDa. It belongs to the G protein-coupled receptor superfamily which is known for transmitting signals from outside the cell to the interior. GPR137 is mostly expressed in various tissues including brain kidney and liver highlighting its broad physiological roles. Due to its structure and signaling capabilities GPR137 plays a significant role in intracellular communication and cellular responses.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nResearchers identify GPR137 as a protein involved in modulating cellular growth survival and differentiation. It functions as a critical part of cellular signaling networks often forming complexes with other receptor proteins to enhance or inhibit signaling pathways. In some studies GPR137 has shown associations with cellular processes like autophagy and apoptosis indicating its importance in maintaining cellular homeostasis. Its expression in multiple tissues suggests it may perform diverse functions depending on the tissue type.\u003cbr\u003e\nPathways\u003cbr\u003e\nSeveral studies have linked GPR137 to the mTOR signaling and Wnt pathways. These pathways are essential for cell growth proliferation and differentiation. GPR137 interacts with components like mTORC1 in the mTOR signaling pathway which influences protein synthesis and energy metabolism. In the Wnt pathway GPR137 may work alongside proteins like β-catenin contributing to the regulation of gene expression. Understanding its role in these pathways can provide valuable insight into its functions and interactions with other cellular components.\u003cbr\u003e\nGPR137 has connections to cancer and neurodegenerative diseases. Changes in its expression or function can influence the progression of tumors by affecting cell proliferation and death. Additionally its involvement in the mTOR and Wnt pathways suggests a role in neurodegenerative diseases where these pathways are disrupted. GPR137 can interact with proteins like p53 in cancer linking it to mechanisms of cell cycle regulation and apoptosis. Its relationship with these diseases positions GPR137 as a potential target in therapeutic strategies.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845164781737,"sku":"ab277179","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab277179","provider":"Iright","version":"1.0","type":"link"}