{"product_id":"abcam-ab277490","title":"Abcam, ab277490, Anti-KLRF1 antibody [EPR23633-150] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal KLRF1 antibody. Carrier free. Suitable for Flow Cyt and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR23633-150,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab277490 is the carrier-free version of\u003cbr\u003e\nab256809\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nKLRF1 also known as CD314 or NKp80 is a receptor protein found primarily on natural killer (NK) cells with a significant mass of about 30 kDa. Researchers have identified its expression mainly in tissues rich in NK cells such as the spleen and peripheral blood. This receptor structurally belongs to the C-type lectin-like domain family and plays an important role in the immune response by binding to the CLEC2B ligand on target cells facilitating NK cell activation and cytotoxicity.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIn immune surveillance and homeostasis KLRF1 acts as an important activating receptor on natural killer cells. It does not form a complex but works independently to control cellular immune responses by recognizing stress-induced ligands on target cells. Upon interaction with its ligand KLRF1 triggers a cascade of intracellular signals that promote cytotoxic activity and cytokine secretion contributing to the elimination of virally infected or transformed cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nIn the context of innate immune response signaling KLRF1 interacts with pathways involving NK cell-mediated cytotoxicity. KLRF1 engagement stimulates pathways similar to those activated by other receptors in the natural killer cell repertoire such as KLRK1 (NKG2D). These interactions play roles in maintaining balance within the immune system by modulating NK cell activity and ensuring efficient target cell elimination.\u003cbr\u003e\nKLRF1 has implications in immune system-related conditions such as cancers and viral infections. Altered expression or function of KLRF1 may contribute to the escape of tumor cells from immune surveillance or decreased viral clearance. Associations with proteins like KLRD1 (CD94) in certain hematological malignancies suggest a role for KLRF1 in disease pathogenesis where NK cell dysfunction is present underlining its significance in developing therapeutic interventions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848568885417,"sku":"ab277490","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab277490","provider":"Iright","version":"1.0","type":"link"}