{"product_id":"abcam-ab281002","title":"Abcam, ab281002, Anti-Neuropeptide Y antibody [EPR23483-22] - BSA and Azide free (Detector)","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Neuropeptide Y antibody. Carrier free. Suitable for sELISA and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR23483-22,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:sELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab281002 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human NPY. The recommended pair for sandwich ELISA is:\u003cbr\u003e\nCapture:\u003cbr\u003e\nab281152\u003cbr\u003e\n, Human NPY Capture Antibody (unconjugated)\u003cbr\u003e\nDetector: ab281002, Human NPY Detector Antibody (unconjugated)\u003cbr\u003e\nThe reference range value is 0.39-50 ng\/mL.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nSandwich ELISA\u003cbr\u003e\nThe recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNeuropeptide Y (NPY) a 36 amino acid peptide functions mechanically as a neurotransmitter in the central and peripheral nervous systems. Alternate names include porcine peptide YY. The molecular weight of Neuropeptide Y is approximately 4 kDa. It expresses primarily in regions of the brain such as the hypothalamus and sympathetic nervous system as well as in other tissues including the heart adrenal glands and white adipose tissue.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNeuropeptide Y plays an important role in regulating various physiological processes. It is not typically part of a complex but acts directly on specific receptors mainly Y1 Y2 Y4 and Y5. Neuropeptide Y affects food intake behavior stress response circadian rhythm and cardiovascular regulation. It does so by modulating the release of other neurotransmitters or hormones having a significant impact on energy balance and homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nNeuropeptide Y plays a pivotal role in neurobiological signaling pathways especially those involving stress and energy homeostasis. In the hypothalamus NPY influences energy balance by interacting with the melanocortin pathway an important modulator of appetite and energy expenditure. It also interacts with proteins such as pro-opiomelanocortin (POMC) in these signaling pathways highlighting its integration into complex physiological processes that maintain homeostasis.\u003cbr\u003e\nNeuropeptide Y shows a significant connection to metabolic disorders and stress-related conditions. Dysregulation of NPY signaling has been implicated in obesity given its role in promoting food intake and energy storage. Additionally altered Neuropeptide Y activity links to anxiety and depression diseases involving stress-response dysregulation. Proteins like leptin which interacts with NPY in pathways governing hunger and energy allocation provide another layer of regulation affecting these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851279421609,"sku":"ab281002","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab281002","provider":"Iright","version":"1.0","type":"link"}