{"product_id":"abcam-ab284035","title":"Abcam, ab284035, Anti-SARS-CoV-2 Protein 9b antibody [EPR25043-28]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal SARS CoV-2 ORF9b protein antibody. Suitable for WB, I-ELISA and reacts with Recombinant fragment - SARS-CoV-2 samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR25043-28,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nApplications:WB, I-ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nProtein 9b and ORF9b are alternative names for Uniprot P0DTD2.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe SARS-CoV-2 ORF9b protein sometimes referred to as ORF9b protein is a small accessory protein with a mass of approximately 9 kDa. This protein is encoded by the open reading frame 9b (ORF9b) of the SARS-CoV-2 virus. It is expressed within the infected host cells where the virus replicates. ORF9b protein localizes to the mitochondria and plays a structural role in modulating host cellular processes during infection.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe ORF9b protein interacts with the host immune system by inhibiting the type I interferon signaling pathway. This protein acts as a part of the viral evasion mechanisms allowing SARS-CoV-2 to escape host immune detection. ORF9b does not form part of a larger protein complex by itself but operates through interactions with host proteins affecting the host's antiviral responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nORF9b disrupts the type I interferon immune signaling pathway one of the host's key antiviral defenses. It interacts with proteins such as Tom70 a mitochondrial import receptor. This interaction hampers the signaling cascade leading to reduced production of interferon which normally activates immune responses against viral infections. ORF9b's role in these pathways directly counteracts the host's ability to mount a timely defense against SARS-CoV-2 infection.\u003cbr\u003e\nORF9b is associated with the pathogenesis of COVID-19 the disease caused by SARS-CoV-2. Its ability to suppress immune signaling can contribute to the severity of COVID-19 by enabling viral persistence and exacerbating inflammatory responses. Additionally ORF9b interaction with ubiquitin system proteins such as MAVS facilitates immune evasion highlighting its role in the disease progression and severity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855765950633,"sku":"ab284035","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab284035","provider":"Iright","version":"1.0","type":"link"}