{"product_id":"abcam-ab284808","title":"Abcam, ab284808, Anti-FGFR1 alpha (phospho Y654) antibody [EP843(2)] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Monoclonal FGFR1 phospho Y654 antibody. Carrier free. Suitable for Dot, I-ELISA, WB and reacts with Synthetic peptide, Synthetic peptide - Human, Recombinant full length protein - Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EP843(2),\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:I-ELISA, WB, DotSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody recognizes FGFR1 (phospho Y654), FGFR2 (phospho Y657), FGFR3 (phospho Y648) and FGFR4 (phospho Y643).\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab284808 is the carrier-free version of\u003cbr\u003e\nab134043\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFGFR1 alpha also known as Fibroblast Growth Factor Receptor 1 is a transmembrane protein with a mass of approximately 104 kDa. It functions as a receptor tyrosine kinase that mediates phosphorylation events when it binds to its ligand the fibroblast growth factors. Upon activation FGFR1 alpha undergoes dimerization and autophosphorylation on specific tyrosine residues. FGFR1 alpha is widely expressed in tissues like the brain lungs and kidneys indicating its involvement in diverse physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe FGFR1 alpha acts as a significant regulator of cell differentiation proliferation and survival. It forms part of a complex network that is critical in tissue development and homeostasis. The interactions of FGFR1 alpha with its ligands can activate several downstream signaling pathways that influence cell behavior. Its role in neural tissue development is particularly important as it supports early neuronal differentiation and survival.\u003cbr\u003e\nPathways\u003cbr\u003e\nFGFR1 alpha features prominently in the MAPK\/ERK and PI3K\/AKT signaling cascades. These pathways manage essential cellular functions such as growth metabolism and apoptosis. FGFR1 alpha works closely with other receptors and proteins like SHC and GRB2 which propagate signals through these pathways to achieve precise cellular outcomes. These interactions exemplify the receptor’s embeddedness in tightly regulated signaling networks vital for maintaining cellular functions.\u003cbr\u003e\nFGFR1 alpha mutations and aberrant signaling correlate with conditions such as cancer and skeletal developmental disorders. In particular it has connections to syndromes like Pfeiffer syndrome where FGFR1 mutations lead to cranial deformities. In cancer FGFR1 alpha may partner with oncogenic proteins like FRS2 facilitating a microenvironment conducive to tumor proliferation and angiogenesis. Understanding these relationships assists in identifying therapeutic targets and developing interventions for FGFR1 alpha-related conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860580225193,"sku":"ab284808","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab284808","provider":"Iright","version":"1.0","type":"link"}