{"product_id":"abcam-ab285404","title":"Abcam, ab285404, LGK974","description":"\u003cp\u003eSize: 1mg \/ 5mg\u003cbr\u003e\nMW 396.4 Da, Purity \u0026gt;98%. LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC₅₀ = ~0.4 nM). GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models, and is well-tolerated. In addition, head and neck cancer cell lines with loss-of-function mutations in the Notch signaling pathway have a high response rate to LGK974.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1243244-14-5,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:396.4 Da,\u003cbr\u003e\nMolecular formula:C23H20N6O,\u003cbr\u003e\nPubChem:46926973,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:DMSO (~35 mg\/ml),\u003cbr\u003e\nBiochemical name:2-(2',3-Dimethyl-[2,4'-bipyridin]-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide,\u003cbr\u003e\nBiological description:LGK-974 is a potent and specific inhibitor of Porcupine (porcn), a Wnt-specific acyltransferase (IC₅₀ = ~0.4 nM). GK974 potently inhibits Wnt signaling, has strong efficacy in rodent tumor models, and is well-tolerated. In addition, head and neck cancer cell lines with loss-of-function mutations in the Notch signaling pathway have a high response rate to LGK974.,\u003cbr\u003e\nCanonical smiles:CC1=CC(=CN=C1C2=CC(=NC=C2)C)CC(=O)NC3=NC=C(C=C3)C4=NC=CN=C4,\u003cbr\u003e\nInChi:InChI=1S\/C23H20N6O\/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20\/h3-10,12-14H,11H2,1-2H3,(H,27,29,30),\u003cbr\u003e\nInChiKey:XXYGTCZJJLTAGH-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:2-[5-methyl-6-(2-methylpyridin-4-yl)pyridin-3-yl]-N-(5-pyrazin-2-ylpyridin-2-yl)acetamide\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called 2645 LGK974. 2645-1 is the same size as the 1 mg size of ab285404.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847495831721,"sku":"ab285404","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab285404","provider":"Iright","version":"1.0","type":"link"}