{"product_id":"abcam-ab286214","title":"Abcam, ab286214, Baloxavir Marboxil","description":"\u003cp\u003eSize: 100mg\u003cbr\u003e\nMW 571.6 Da, Purity 99%. A prodrug that is metabolised to the active form baloxavir acid also known as S‐033447. S‐033447 is a small molecule inhibitor of the cap‐dependent endonuclease of influenza A and B viruses. It has shown nanomolar antiviral activity against influenza A and B viruses in vitro. In murine models of seasonal influenza and avian influenza A(H5N1) or A(H7N9), orally administered baloxavir showed a rapid reduction in pulmonary viral loads and decreased mortality. Baloxavir significantly reduced the time for alleviation of symptoms and reduced virus titres at 24 and 48 hours post‐treatment at three different doses (10 mg, 20 mg and 40 mg) in a phase II study with patients experiencing uncomplicated influenza.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:1985606-14-1,\u003cbr\u003e\nPurity:99%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:571.6 Da,\u003cbr\u003e\nMolecular formula:C27H23F2N3O7S,\u003cbr\u003e\nPubChem:124081896,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:~30 mg\/ml in DMSO (May need ultrasonication),\u003cbr\u003e\nBiochemical name:Baloxavir marboxil,\u003cbr\u003e\nBiological description:A prodrug that is metabolised to the active form baloxavir acid also known as S‐033447. S‐033447 is a small molecule inhibitor of the cap‐dependent endonuclease of influenza A and B viruses. It has shown nanomolar antiviral activity against influenza A and B viruses in vitro. In murine models of seasonal influenza and avian influenza A(H5N1) or A(H7N9), orally administered baloxavir showed a rapid reduction in pulmonary viral loads and decreased mortality. Baloxavir significantly reduced the time for alleviation of symptoms and reduced virus titres at 24 and 48 hours post‐treatment at three different doses (10 mg, 20 mg and 40 mg) in a phase II study with patients experiencing uncomplicated influenza.,\u003cbr\u003e\nCanonical smiles:COC(=O)OCOC1=C2C(=O)N3CCOCC3N(N2C=CC1=O)C4C5=C(CSC6=CC=CC=C46)C(=C(C=C5)F)F,\u003cbr\u003e\nIsomeric smiles:COC(=O)OCOC1=C2C(=O)N3CCOC[C@H]3N(N2C=CC1=O)[C@H]4C5=C(CSC6=CC=CC=C46)C(=C(C=C5)F)F,\u003cbr\u003e\nInChi:InChI=1S\/C27H23F2N3O7S\/c1-36-27(35)39-14-38-25-19(33)8-9-31-24(25)26(34)30-10-11-37-12-21(30)32(31)23-15-6-7-18(28)22(29)17(15)13-40-20-5-3-2-4-16(20)23\/h2-9,21,23H,10-14H2,1H3\/t21-,23+\/m1\/s1,\u003cbr\u003e\nInChiKey:RZVPBGBYGMDSBG-GGAORHGYSA-N,\u003cbr\u003e\nIUPAC Name:[(3R)-2-[(11S)-7,8-difluoro-6,11-dihydrobenzo[c][1]benzothiepin-11-yl]-9,12-dioxo-5-oxa-1,2,8-triazatricyclo[8.4.0.03,8]tetradeca-10,13-dien-11-yl]oxymethyl methyl carbonate\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B3014 Baloxavir marboxil. B3014-500 is the same size as the 500 mg size of ab286214.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store in the dark, Store under desiccating conditions, This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847497339049,"sku":"ab286214","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab286214","provider":"Iright","version":"1.0","type":"link"}