{"product_id":"abcam-ab287009","title":"Abcam, ab287009, Emetine dihydrochloride hydrate","description":"\u003cp\u003eSize: 50mg \/ 250mg\u003cbr\u003e\nMW 571.6 Da, Purity \u0026gt;98%. An alkaloid derived from ipecac root. Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Also, selectively inhibits multiple glioblastoma (GBM) stem cells-enriched cultures. It has been found to inhibit endemic human coronaviruses and MERS-CoV in cell culture and cell entry assays.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:7083-71-8,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:571.6 Da,\u003cbr\u003e\nMolecular formula:C29H44Cl2N2O5,\u003cbr\u003e\nPubChem:201899,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in water to 100 mM,\u003cbr\u003e\nBiochemical name:Emetine dihydrochloride hydrate,\u003cbr\u003e\nBiological description:An alkaloid derived from ipecac root. Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Also, selectively inhibits multiple glioblastoma (GBM) stem cells-enriched cultures. It has been found to inhibit endemic human coronaviruses and MERS-CoV in cell culture and cell entry assays.,\u003cbr\u003e\nCanonical smiles:CCC1CN2CCC3=CC(=C(C=C3C2CC1CC4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC.O.Cl.Cl,\u003cbr\u003e\nIsomeric smiles:CC[C@H]1CN2CCC3=CC(=C(C=C3[C@@H]2C[C@@H]1C[C@@H]4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC.O.Cl.Cl,\u003cbr\u003e\nInChi:InChI=1S\/C29H40N2O4.2ClH.H2O\/c1-6-18-17-31-10-8-20-14-27(33-3)29(35-5)16-23(20)25(31)12-21(18)11-24-22-15-28(34-4)26(32-2)13-19(22)7-9-30-24;;;\/h13-16,18,21,24-25,30H,6-12,17H2,1-5H3;2*1H;1H2\/t18-,21-,24+,25-;;;\/m0...\/s1,\u003cbr\u003e\nInChiKey:IZTPMTAWOCEKKM-VXMYZLRESA-N,\u003cbr\u003e\nIUPAC Name:(2S,3R,11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine;hydrate;dihydrochloride\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B2339 Emetine dihydrochloride hydrate. B2339-50 is the same size as the 50 mg size of ab287009.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847498879145,"sku":"ab287009","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab287009","provider":"Iright","version":"1.0","type":"link"}