{"product_id":"abcam-ab287032","title":"Abcam, ab287032, STING Antagonist (H-151)","description":"\u003cp\u003eSize: 5mg\u003cbr\u003e\nMW 279.34 Da, Purity \u0026gt;98%. H-151 is a potent antagonist of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduces systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-\/- mice.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:941987-60-6,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:SolidSee storage information,\u003cbr\u003e\nMolecular weight:279.34 Da,\u003cbr\u003e\nMolecular formula:C17H17N3O,\u003cbr\u003e\nPubChem:7616033,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:Soluble in DMSO to \u0026gt;75 mM,\u003cbr\u003e\nBiochemical name:1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea,\u003cbr\u003e\nBiological description:H-151 is a potent antagonist of the signaling molecule STING in mouse and human cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. It reduces systemic cytokine response in mice treated with the STING agonist 10-carboxymethyl-9-acridanone and showed efficacy in Trex-\/- mice.,\u003cbr\u003e\nCanonical smiles:CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32,\u003cbr\u003e\nInChi:InChI=1S\/C17H17N3O\/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16\/h3-11,18H,2H2,1H3,(H2,19,20,21),\u003cbr\u003e\nInChiKey:UJZDIKVQFMCLBE-UHFFFAOYSA-N,\u003cbr\u003e\nIUPAC Name:1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B2395 STING Antagonist, H-151. B2395-5 is the same size as the 5 mg size of ab287032.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847499436201,"sku":"ab287032","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab287032","provider":"Iright","version":"1.0","type":"link"}