{"product_id":"abcam-ab287084","title":"Abcam, ab287084, Muramyl Dipeptide","description":"\u003cp\u003eSize: 1mg \/ 5mg\u003cbr\u003e\nMW 492.5 Da, Purity \u0026gt;98%. Muramyl dipeptide is a synthetic immunoreactive peptide that activates NOD2 receptors. Induces polarization of proinflammatory Ly6Chigh into Ly6Clow patrolling monocytes. Also inhibits HIV replication in CD4⁺ H9 lymphocytes.\u003cbr\u003e\nKey facts\u003cbr\u003e\nCAS number:53678-77-6,\u003cbr\u003e\nPurity:\u0026gt;98%,\u003cbr\u003e\nForm:LyophilizedSee storage information,\u003cbr\u003e\nMolecular weight:492.5 Da,\u003cbr\u003e\nMolecular formula:C19H32N4O11,\u003cbr\u003e\nPubChem:11620162,\u003cbr\u003e\nNature:Synthetic,\u003cbr\u003e\nSolubility:\u0026gt;40 mg\/ml in Water,\u003cbr\u003e\nBiochemical name:Adjuvant Peptide,\u003cbr\u003e\nBiological description:Muramyl dipeptide is a synthetic immunoreactive peptide that activates NOD2 receptors. Induces polarization of proinflammatory Ly6Chigh into Ly6Clow patrolling monocytes. Also inhibits HIV replication in CD4⁺ H9 lymphocytes.,\u003cbr\u003e\nCanonical smiles:CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C,\u003cbr\u003e\nIsomeric smiles:C[C@@H](C(=O)N[C@H](CCC(=O)O)C(=O)N)NC(=O)[C@@H](C)O[C@H]1[C@@H]([C@H](OC([C@@H]1NC(=O)C)O)CO)O,\u003cbr\u003e\nInChi:InChI=1S\/C19H32N4O11\/c1-7(17(30)23-10(16(20)29)4-5-12(26)27)21-18(31)8(2)33-15-13(22-9(3)25)19(32)34-11(6-24)14(15)28\/h7-8,10-11,13-15,19,24,28,32H,4-6H2,1-3H3,(H2,20,29)(H,21,31)(H,22,25)(H,23,30)(H,26,27)\/t7-,8+,10+,11+,13+,14+,15+,19?\/m0\/s1,\u003cbr\u003e\nInChiKey:BSOQXXWZTUDTEL-QAQREVAFSA-N,\u003cbr\u003e\nIUPAC Name:(4R)-4-[[(2S)-2-[[(2R)-2-[(3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropanoyl]amino]propanoyl]amino]-5-amino-5-oxopentanoic acid\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product is manufactured by BioVision, an Abcam company and was previously called B2532 Muramyl Dipeptide. B2532-1 is the same size as the 1 mg size of ab287084.\u003cbr\u003e\nProtect from moisture.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe CARD15\/NOD2 and NLRP3 proteins have important roles in immune response mechanisms. CARD15 also known as NOD2 is a cytoplasmic protein with a mass of about 115 kDa. It expresses in monocytes macrophages and dendritic cells. NLRP3 a member of the NOD-like receptor family weighs approximately 118 kDa and expresses predominantly in myeloid cells. Both proteins recognize pathogen-associated molecular patterns especially components of bacterial peptidoglycans like muramyl dipeptide which activates innate immune signaling.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThese proteins detect intracellular changes related to infections or cellular stress. CARD15\/NOD2 and NLRP3 function as part of multiprotein complexes called inflammasomes. These complexes trigger inflammation through the activation of caspase-1 which then processes pro-inflammatory cytokines like interleukin-1β. NOD2 responds specifically to muramyl dipeptide leading to nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway activation which enhances inflammation response.\u003cbr\u003e\nPathways\u003cbr\u003e\nBoth CARD15\/NOD2 and NLRP3 are integral to immune system signaling pathways. NOD2 is central to the NF-κB signaling pathway. It also interacts with proteins like RIP2 to modulate immune response. NLRP3 activates inflammasomes contributing to the IL-1β processing pathway. These pathways influence how the immune system identifies and counteracts bacterial threats.\u003cbr\u003e\nDysfunctions in CARD15\/NOD2 and NLRP3 have connections to inflammatory diseases. Mutations in NOD2 associate with Crohn's disease affecting intestinal inflammation. NLRP3 mutations relate to cryopyrin-associated periodic syndromes (CAPS) leading to systemic autoinflammatory reactions. Associations with other proteins such as IL-1β are critical because their dysregulation in these diseases highlights the key roles of CARD15\/NOD2 and NLRP3 in maintaining immune homeostasis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46847495635113,"sku":"ab287084","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab287084","provider":"Iright","version":"1.0","type":"link"}