{"product_id":"abcam-ab289639","title":"Abcam, ab289639, Anti-mGluR1a antibody [EPR24160-173] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal GRM1 antibody. Carrier free. Suitable for IHC-Fr, IP, WB, IHC-P and reacts with Rat, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR24160-173,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Rat,\u003cbr\u003e\nApplications:WB, IHC-Fr, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab289639 is the carrier free version of\u003cbr\u003e\nab259888\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMGluR1a also known as metabotropic glutamate receptor 1a is a G-protein coupled receptor with a mass of approximately 153 kDa. This receptor binds glutamate an excitatory neurotransmitter and initiates intracellular signaling by activating G-proteins. It is expressed in various regions of the brain such as the cerebellum hippocampus and olfactory bulb. The receptor is involved in modulating several synaptic processes by influencing the release of neurotransmitters.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGlutamate receptor mGluR1a plays a significant role in neuroplasticity and synaptic transmission. It does not act alone but is part of a larger group of metabotropic glutamate receptors. These receptors participate in both excitatory and inhibitory signaling pathways affecting signal regulation and neuron connectivity. mGluR1a contributes to learning and memory processes through its ability to modulate synaptic strength.\u003cbr\u003e\nPathways\u003cbr\u003e\nMGluR1a is an important component in the phosphatidylinositol signaling system and the glutamatergic synapse pathway. Both pathways are related to calcium ion homeostasis and protein trafficking in neurons. Among the related proteins Homer and Shank play a role in the mGluR1a signaling complex and aid in its function within these pathways affecting synaptic structure and plasticity.\u003cbr\u003e\nMGluR1a is associated with several neuropathological conditions. Alterations in its function or expression can contribute to the development of neurodegenerative diseases like Alzheimer’s disease and psychiatric disorders such as schizophrenia. The receptor interacts with proteins like amyloid precursor protein (APP) and SynGAP which play roles in the etiology and progression of these conditions. Dysregulation of mGluR1a signaling may affect neuronal death and lead to cognitive defects seen in these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851633119401,"sku":"ab289639","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab289639","provider":"Iright","version":"1.0","type":"link"}