{"product_id":"abcam-ab289975","title":"Abcam, ab289975, Anti-HCF-1 \/ Host Cell Factor C1 antibody [EPR25290-18]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal HCF-1 \/ Host Cell Factor C1 antibody. Suitable for ICC\/IF, WB, Flow Cyt (Intra), IHC-P and reacts with Mouse, Human, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR25290-18,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Mouse, Human,\u003cbr\u003e\nApplications:ICC\/IF, Flow Cyt (Intra), IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Host Cell Factor C1 commonly known as HCF-1 is a large protein with a mass of approximately 203 kDa. It is widely expressed in many tissues and it plays a significant role in cellular processes such as transcription regulation. HCF-1 can be commonly found in the nucleus and cytoplasm and through various alternative names it is sometimes referred to as HCF-1 HCF-1 stores or HCP48BCF. Its mechanical action involves the regulation of transcription through interactions with other transcription factors and cofactors.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIn multiple cellular frameworks HCF-1 operates as a part of the Set1\/COMPASS complex which is pivotal for transcriptional coactivation. It engages in the regulation of cell cycle progression acting as a co-regulator with transcription factors associated with cell proliferation. HCF-1 influences chromatin structure permitting changes in gene expression. This dynamic regulation facilitates processes like DNA replication and repair emphasizing its role in maintaining genomic stability.\u003cbr\u003e\nPathways\u003cbr\u003e\nSeveral cellular pathways involve HCF-1 including the herpes simplex virus (HSV) replication pathway and the E2F transcriptional pathway. In the HSV pathway HCF-1 interacts with viral components to regulate gene expression. In the context of E2F pathways HCF-1 links with E2F transcription factors to control cell cycle entry and progression. Such interactions highlight its central role in coordinating cellular responses to both internal and external stimuli.\u003cbr\u003e\nHCF-1 connections arise prominently in cancer and neurodevelopmental disorders. Its deregulation is often seen in cancer where it can interact with oncoproteins such as c-Myc modulating oncogenic transcription. HCF-1's role in transcriptional regulation and chromatin remodeling ties it to neurodevelopmental disorders where associated proteins like SETD1A are critical. Understanding these connections highlights the therapeutic potential of targeting HCF-1 in disease contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850294841513,"sku":"ab289975","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab289975","provider":"Iright","version":"1.0","type":"link"}