{"product_id":"abcam-ab300443","title":"Abcam, ab300443, Anti-Oxytocin Receptor antibody [EPR24409-146]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nAnti-Oxytocin Receptor antibody [EPR24409-146] (ab300443) is a rabbit monoclonal antibody detecting Oxytocin Receptor in  Western Blot, ICC\/IF . Suitable for  Human, Mouse, Rat . - Biophysical QC for unrivalled batch-batch consistency\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR24409-146,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Oxytocin Receptor antibody [EPR24409-146] (ab300443) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunocytochemistry\/immunofluorescence (ICC\/IF) in Human, Mouse, Rat samples.\u003cbr\u003e\nTrial sizes available!\u003cbr\u003e\nTest your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.\u003cbr\u003e\nDiscover our selection of trial-size antibodies\u003cbr\u003e\nOther related products\u003cbr\u003e\nWe have a range of other formats of antibody clone [EPR24409-146] also available for your convenience: ab300443, Carrier free -\u003cbr\u003e\nab300444\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe oxytocin receptor (OTR) also known as OXTR is a G-protein-coupled receptor that primarily binds the neuropeptide hormone oxytocin. It has a molecular mass of approximately 43 kDa. This receptor is expressed in diverse tissues including the brain uterus mammary glands and heart. It plays a significant role in signal transduction processes converting extracellular hormonal signals into specific intracellular effects that facilitate various physiological functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe oxytocin receptor exhibits involvement in many reproductive and social behaviors. Despite not functioning as part of a larger complex OTR activation facilitates processes such as uterine contraction milk ejection and social bonding. Activation of this receptor influences neuronal circuits in the brain supporting behaviors linked to emotion and social memory which are fundamental to maternal behaviors and pair bonding.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe oxytocin receptor participates in critical signaling cascades including the phosphatidylinositol-calcium second messenger system. Through this pathway the receptor activates protein kinase C and increases intracellular calcium levels. This pathway often involves interaction with other proteins such as vasopressin receptors which have overlapping functions in fluid balance and cardiovascular regulation.\u003cbr\u003e\nThe oxytocin receptor has associations with conditions like autism spectrum disorder and postpartum depression. These disorders suggest that altered oxytocin receptor signaling may contribute to atypical social behavior and mood regulation. Additionally the receptor's interaction with proteins like the vasopressin receptor influences susceptibility to these neuropsychiatric conditions highlighting its role in neurological health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850313781417,"sku":"ab300443","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab300443","provider":"Iright","version":"1.0","type":"link"}