{"product_id":"abcam-ab302493","title":"Abcam, ab302493, Anti-RILPL1 antibody [MJF-R41-21] (BSA and Azide free)","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal RILPL1 antibody. Carrier free. Suitable for WB, ICC\/IF, IP and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:MJF-R41-21,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WB, IP, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nCollaborations\u003cbr\u003e\nThis antibody was developed with support from The Michael J. Fox Foundation.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nRILPL1 also known as Rab interacting lysosomal protein-like 1 is a protein involved in cellular processes related to lysosomal trafficking. It has a molecular weight of approximately 45 kDa. RILPL1 expresses itself in a variety of tissues notably in the brain. The protein plays a significant role in intracellular transport mechanisms specifically in modulating the interaction between lysosomal structures and other cellular components.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nRILPL1 influences neuronal functions and is implicated in the regulation of ciliogenesis and other cellular morphogenesis processes. It often associates with components of the cytoskeletal network acting within protein complexes that contribute to cell shape and stability. This involves aiding in processes like axon transport which is critical for maintaining neuronal connectivity and function across different regions of the brain.\u003cbr\u003e\nPathways\u003cbr\u003e\nRILPL1 is a part of cellular pathways involving lysosome positioning and transport. It interacts with motor proteins such as dynein and kinesin essential for microtubule-based movement. RILPL1's role in these pathways highlights its contribution to maintaining lysosomal homeostasis and transportation impacting processes like autophagy and endocytosis.\u003cbr\u003e\nRILPL1 has been linked to neurodegenerative diseases like Huntington’s disease where disruption of lysosomal trafficking can lead to cellular pathology. The protein's interaction with the Huntingtin protein suggests its involvement in pathways that when dysregulated contribute to disease progression. Additionally irregularities in RILPL1 function may relate to ciliopathies disorders affecting cilia formation and function due to its role in driving key processes in neuronal cells.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851634659497,"sku":"ab302493","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab302493","provider":"Iright","version":"1.0","type":"link"}