{"product_id":"abcam-ab302543","title":"Abcam, ab302543, Anti-Neogenin antibody [EPR25220-56] (BSA and Azide free)","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Neogenin antibody. Carrier free. Suitable for WB, ICC\/IF, IP and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR25220-56,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNeogenin also known as NEO1 acts as an important receptor involved in cell adhesion migration and neural development. It weighs approximately 186 kDa. Neogenin binds to netrins and repulsive guidance molecules (RGMs) playing a role in the organization of neural circuits. Expressed in tissues such as the developing nervous system muscle tissue and some cancer cells Neogenin collaborates with cellular structures to influence growth and directionality.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNeogenin influences cell orientation and axon guidance. It forms part of receptor complexes that include proteins like RGM and attracts molecules involved in neural signal transmission. Through these complexes Neogenin impacts processes such as synaptic development and neuronal positioning. Its activity allows for proper nervous system formation and function contributing to precise cellular communication.\u003cbr\u003e\nPathways\u003cbr\u003e\nNeogenin participates in the signaling pathways important for neural pattern formation and tissue structuring. The Netrin signaling pathway is important for neuron navigation where Neogenin interacts with proteins like DCC (Deleted in Colorectal Cancer). Neogenin also engages in the Bone Morphogenetic Protein (BMP) pathways regulating cellular differentiation and tissue architecture.\u003cbr\u003e\nNeogenin mutations or irregular expressions often associate with neurological disorders and cancer. In particular its dysregulation links to conditions such as brain tumors and congenital brain malformations. In cancer pathways Neogenin connects with proteins like Netrin-1 influencing pathways that lead to tumorigenesis and tumor progression. Understanding Neogenin interactions can help in developing therapeutic strategies targeting these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860394725545,"sku":"ab302543","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab302543","provider":"Iright","version":"1.0","type":"link"}