{"product_id":"abcam-ab302712","title":"Abcam, ab302712, Anti-GLTSCR1 antibody [EPR26561-76]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal GLTSCR1 antibody. Suitable for Flow Cyt (Intra), ICC\/IF, IHC-P, WB and reacts with Mouse, Human, Rat samples. Cited in 1 publication.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26561-76,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Rat, Mouse, Human,\u003cbr\u003e\nApplications:IHC-P, WB, ICC\/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nGLTSCR1 also known as Glioma Tumor Suppressor Candidate Region Gene 1 is a protein that functions in chromatin remodeling. This protein plays an important role in regulating gene expression by impacting chromatin structure making genes accessible or inaccessible as needed. The molecular mass of GLTSCR1 is approximately 110 kDa. Expression of GLTSCR1 happens in various human tissues with notable presence in brain tissues where it might influence neurological functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nGLTSCR1 operates as part of the larger BAF chromatin remodeling complex which is vital for modifying chromatin architecture. This complex aids transcription regulation and helps control cellular differentiation. The protein acts to influence the organization of chromatin which can lead in turn to the activation or repression of certain genes. This function positions GLTSCR1 as an important player in maintaining cellular homeostasis and determining cell fate.\u003cbr\u003e\nPathways\u003cbr\u003e\nGLTSCR1 is key in transcriptional regulation pathways and plays a role in neural development. The protein interacts with other components within the BAF complex like BRG1 and BAF155 thereby exerting influence across pathways linked to DNA accessibility and transcription. Its activity can impact pathways such as the Wnt signaling pathway where its chromatin remodeling capabilities interface with signal transduction processes influencing cell division and development.\u003cbr\u003e\nAberrations in GLTSCR1 are linked to glioblastoma multiforme and neurodevelopmental disorders. In glioblastoma disruptions in chromatin remodeling and gene expression can lead to uncontrolled cell growth. The disorder may involve interactions with other protein complexes including ones containing MLL1 involved in histone modification suggesting a wide-net impact on epigenetic regulation. Additionally its association with the nervous system development links it to certain neurodevelopmental anomalies indicating its broader significance in maintaining nervous system integrity.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850295988393,"sku":"ab302712","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab302712","provider":"Iright","version":"1.0","type":"link"}