{"product_id":"abcam-ab302925","title":"Abcam, ab302925, Anti-UNC5C antibody [EPR24190-37] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal UNC5C antibody. Carrier free. Suitable for WB and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR24190-37,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Storage information-Do Not Freeze\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUNC5C also known as Unc-5 Netrin Receptor C serves as a receptor for netrin a protein that guides axonal growth. It is a member of the UNC5 family and plays an important role in cell migration and positioning. The molecular mass of UNC5C is approximately 103 kDa. It is mainly expressed in the nervous system specifically in the developing brain and spinal cord but can also be found in other tissues to a lesser degree. Its expression pattern suggests a role diverse from just the nervous system.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUNC5C functions significantly in neuronal guidance and apoptosis regulation. It forms part of a receptor complex together with DCC (Deleted in Colorectal Carcinoma) when binding with netrin-1 another important protein in axon guidance. This interaction influences neuronal cells’ behavior by repelling or attracting axons depending on the context. Beyond its interaction with netrin-1 UNC5C also engages in signaling pathways promoting or inhibiting cell death adding to its versatile functions in cellular processes.\u003cbr\u003e\nPathways\u003cbr\u003e\nUNC5C participates in the axon guidance and apoptotic processes. It plays an important role in the netrin signaling pathway by interacting with DCC and netrin-1 helping to steer neuron growth cones during development. Additionally it has involvement with the apoptosis pathway where UNC5C interactions can lead to programmed cell death when certain conditions are met such as absence of netrin-1. The protein's function is intricately linked with others like DCC and the netrin family which means it influences and is influenced by key neurodevelopmental pathways.\u003cbr\u003e\nMutations or dysregulation of UNC5C have been associated with neurodegenerative conditions and cancer. Altered UNC5C signaling can contribute to the progression of Alzheimer's disease potentially through the disruption of normal axonal pathfinding or neuronal death mechanisms. In cancer particularly colorectal cancer UNC5C acts as a dependence receptor where its malfunction can trigger inappropriate cell survival contributing to tumorigenesis. UNC5C’s interaction with DCC highlights its role in colorectal cancer emphasizing how its impairment can promote the escape from normal apoptotic signals.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852505469097,"sku":"ab302925","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab302925","provider":"Iright","version":"1.0","type":"link"}