{"product_id":"abcam-ab303447","title":"Abcam, ab303447, ioGlutamatergic Neurons WT (isogenic control) - Human iPSC derived cells","description":"\u003cp\u003eSize: 1000000Cells \/ vial \/ 5000000Cells \/ vial\u003cbr\u003e\nioGlutamatergic Neurons WT (isogenic control) - Human iPSC derived cells available to order. Note that this is suitable for studies with WT Glutamatergic Neurons and also serves as an isogenic control for disease models (HTT, other). - Concentration: 1 million cells\/vial or 5 million cells\/vial\u003cbr\u003e\nKey facts\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nForm:LiquidSee storage information\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nNote that this is suitable for studies with WT Glutamatergic Neurons and also serves as an isogenic control for disease models (HTT, other).\u003cbr\u003e\nioGlutamatergic Neurons have been reprogrammed from human induced pluripotent stem cells (iPSC) using opti-ox, a precise reprogramming technology. Human stem cells, within days, convert into consistent, mature, functional glutamatergic neurons providing a high quality human model for the study of neurological activity and disease.\u003cbr\u003e\nioGlutamatergic Neurons cultures consist mainly of glutamatergic neurons (\u0026gt;80%) characterised by the expression of the glutamate transporter genes VGLUT1 and VGLUT2 (see Figure 1). The minor remaining fraction of the neuronal population express marker genes of cholinergic neurons. A bulk RNA-seq analysis shows that ioGlutamatergic Neurons have a rostral CNS identity and express the classical cortical maker genes FOXG1 and TBR1 (data not shown).\u003cbr\u003e\nIn partnership with bit.bio\u003cbr\u003e\nKaryotype:\u003cbr\u003e\nNormal\u003cbr\u003e\nSeeding Density:\u003cbr\u003e\n30,000 cells\/cm\u003cbr\u003e\nSeeding compatibility:\u003cbr\u003e\n6-, 12-, 24-, 96- and 384-well compatible\u003cbr\u003e\nQuality control:\u003cbr\u003e\nICC and gene expression analysis\u003cbr\u003e\nResearch applications:\u003cbr\u003e\nAcademic research, Drug development, Neurotoxicology, Genetic screening (e.g. CRISPR screening).\u003cbr\u003e\nThis product is subject to limited use licenses from iPS Academia Japan Inc, TET Systems GmbH, ERS Genomics Limited and Sigma-Aldrich Co. LLC and is developed with Bit Bio patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license and patent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845060546729,"sku":"ab303447","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab303447","provider":"Iright","version":"1.0","type":"link"}