{"product_id":"abcam-ab305152","title":"Abcam, ab305152, Anti-Beta Arrestin 1 + 2 antibody [EPR25742-21] - BSA and Azide free (Capture)","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Beta Arrestin 2 antibody. Carrier free. Suitable for sELISA and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR25742-21,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:sELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nSandwich ELISA\u003cbr\u003e\nThe recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nBeta arrestin 1 and beta arrestin 2 sometimes referred to as arrestin beta-1 and arrestin beta-2 are proteins with molecular masses of approximately 47 kDa each. These proteins play important roles in cellular signaling by binding to G protein-coupled receptors (GPCRs) once they are activated and internalized. Beta arrestins are expressed ubiquitously across various tissues in the body including the brain heart and lungs. Their mechanical function involves regulating receptor desensitization recycling and signaling pathways making them key players in modulating cellular responses.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nBeta arrestin 1 and beta arrestin 2 serve as multifunctional adaptors in GPCR signaling complexes. They do not only terminate G-protein signaling but also initiate and modulate G-protein independent pathways leading to diverse cellular outcomes. Beta arrestins participate in receptor internalization by linking GPCRs to components of the endocytic machinery. Through these actions they influence various cellular processes such as cell migration apoptosis and cytoskeletal rearrangements thereby impacting cellular dynamics and communication.\u003cbr\u003e\nPathways\u003cbr\u003e\nBeta arrestin 1 and beta arrestin 2 are integral components in the signaling network of the mitogen-activated protein kinase (MAPK) pathway and the nuclear factor kappa B (NF-kB) pathway. In the MAPK pathway beta arrestins facilitate activation through scaffolding interactions with key proteins like ERK1\/2. In the NF-kB pathway they influence transcriptional activation and cell survival. Their ability to interact with various signaling proteins such as Src clathrin and AP-2 highlights their impactful role in cellular signal transduction.\u003cbr\u003e\nBeta arrestin 1 and beta arrestin 2 have been implicated in various conditions like cardiac dysfunction and cancer progression. In cardiac disorders beta arrestins interact with proteins such as GRK2 which affects heart contractility and cardiac remodeling. In cancer their altered expression or function contributes to tumor growth and metastasis through changes in signaling pathways making them potential targets for therapeutic intervention. Understanding the role of beta arrestins in these diseases helps develop targeted treatments and improve patient outcomes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852510548137,"sku":"ab305152","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab305152","provider":"Iright","version":"1.0","type":"link"}