{"product_id":"abcam-ab307985","title":"Abcam, ab307985, Anti-SNF5\/SMARCB1 antibody [RP23040266] - ChIP Grade","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Recombinant Multiclonal SNF5\/SMARCB1 antibody. Suitable for WB, ChIP and reacts with Human, Mouse samples. Immunogen corresponding to Recombinant Fragment Protein within Human SMARCB1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Multiclonal,\u003cbr\u003e\nClone number:RP23040266,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse,\u003cbr\u003e\nApplications:ChIP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human SMARCB1.Q12824\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat are recombinant multiclonals?\u003cbr\u003e\nRecombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:\u003cbr\u003e\n- The sensitivity of polyclonal antibodies by recognising multiple epitopes\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nView our range of\u003cbr\u003e\nrecombinant multiclonal antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Storage buffer-pH: 7.4Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSNF5\/SMARCB1 also known as INI1 or BAF47 is a member of the SWI\/SNF chromatin remodeling complex. It acts in modifying chromatin structure to regulate gene expression. SNF5\/SMARCB1 possesses a mass of approximately 47 kDa. The protein expresses ubiquitously in various tissues with notable presence in the nucleus. Through its mechanical activity in chromatin remodeling SNF5\/SMARCB1 facilitates transcriptional regulation and chromosomal stability.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSNF5\/SMARCB1 acts as an integral component of the SWI\/SNF complex. This complex functions in altering nucleosome positioning on DNA impacting gene expression linked to cell cycle regulation differentiation and DNA repair. By working within this complex SNF5\/SMARCB1 helps in the activation or repression of specific gene sets based on cellular requirements displaying an essential role in maintaining normal cellular function. The interplay of SNF5\/SMARCB1 with other chromatin-modifying enzymes extends its influence across various genetic pathways.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe involvement of SNF5\/SMARCB1 in the cell cycle and transcription regulation pathways is acknowledged. It participates intimately in the p53 signaling pathway which is critical for cell cycle checkpoints and apoptotic responses. SNF5\/SMARCB1 engages with other proteins such as p53 and RB1 coordinating to maintain genomic integrity and proper transcriptional programming. These pathways spotlight the protein's influence in important cell fate decisions.\u003cbr\u003e\nSNF5\/SMARCB1 mutations or deletions associate closely with malignant rhabdoid tumors an aggressive pediatric cancer and schwannomatosis a disorder involving benign nerve sheath tumors. The loss of SNF5\/SMARCB1 disrupts the SWI\/SNF complex's function triggering unregulated cell proliferation and cancer progression. Within these disorders the SWI\/SNF complex itself which contains other subunits like BRG1 and BRM is also impacted highlighting SMARCB1's critical role in tumor suppression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850187657385,"sku":"ab307985","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab307985","provider":"Iright","version":"1.0","type":"link"}