{"product_id":"abcam-ab308303","title":"Abcam, ab308303, Anti-Neurotensin antibody [EPR27180-62] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Neurotensin antibody. Carrier free. Suitable for IHC-P and reacts with Human, Transfected cell line - Human, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27180-62,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNeurotensin also known by the abbreviation NT is a peptide neurotransmitter that consists of 13 amino acids giving it a relatively modest mass. It is well-known under the name NTS and is mainly expressed in the central nervous system especially within the hypothalamus midbrain and also found in peripheral tissues like the gastrointestinal tract. Neurotensin acts by binding to specific G-protein-coupled receptors such as NTSR1 to mediate its effects.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe peptide neurotransmitter exhibits various functions in both the central and peripheral nervous systems. It can act as a neuromodulator affecting dopamine signaling and impacts the regulation of pain temperature and even food intake. Neurotensin forms part of complexes with other neurotransmitters and interacts closely with pathways related to dopamine suggesting a significant influence on mood and cognition.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe interaction of neurotensin with dopamine pathways is particularly important. It plays a role in modulating the dopaminergic signaling cascades that involve receptor proteins like D2 dopamine receptors. Additionally neurotensin impacts the acute-phase response pathway altering the signaling dynamics in inflammation and immune response.\u003cbr\u003e\nNeurotensin has connections to conditions such as schizophrenia and obesity. Its modulation of dopamine pathways links it to schizophrenia where altered dopamine signaling is evident with potential involvement of proteins like NTSR1 and D2 receptors. Additionally because neurotensin influences food intake and energy balance it relates to obesity with its effects mediated through interactions with other gut-derived peptides and receptors including ghrelin and leptin receptors.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851805872297,"sku":"ab308303","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab308303","provider":"Iright","version":"1.0","type":"link"}