{"product_id":"abcam-ab30833","title":"Abcam, ab30833, Anti-Thyroxine antibody","description":"\u003cp\u003eSize: 500µL\u003cbr\u003e\nRabbit Polyclonal Thyroxine antibody. Suitable for ELISA, RIA and reacts with Human samples. Cited in 4 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ELISA, RIASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nSpecificity:ab30833 recognizes T4: 100%, T3: \u0026lt;= 7.5%.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: 40% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThyroxine also known as T4 is an important hormone secreted by the thyroid gland. It has a molecular weight of approximately 776 Da. Thyroxine circulates mainly bound to carrier proteins such as thyroxine-binding globulin transthyretin and albumin. These proteins transport the hormone throughout the bloodstream permitting it to reach target tissues. The main sites of thyroxine expression include the liver and kidney where it undergoes conversion to its active form called triiodothyronine (T3).\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThyroxine plays an important role in regulating metabolism and growth rate across numerous cell types. It influences a wide range of processes including energy production and consumption thermoregulation and protein synthesis. In cellular contexts thyroxine does not form part of any complex. Instead it freely crosses cell membranes and binds directly to nuclear receptors primarily the thyroid hormone receptor which modifies gene transcription within target cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nThyroxine has central involvement in the hypothalamus-pituitary-thyroid (HPT) axis and metabolic pathway regulation. Through the HPT axis thyroxine influences the release of thyrotropin-releasing hormone and thyroid-stimulating hormone maintaining hormonal balance in the body. In the metabolic pathway thyroxine links with proteins like peroxisome proliferator-activated receptors which oversee lipid metabolism. Its interaction aids in the conversion of macromolecules serving a critical role in daily cellular function.\u003cbr\u003e\nThyroxine levels directly associate with conditions such as hypothyroidism and hyperthyroidism. Low levels of thyroxine cause hypothyroidism leading to fatigue and weight gain while high levels induced during hyperthyroidism cause symptoms like anxiety and rapid heart rate. Thyroid hormone-binding proteins when mutated or dysfunctional exacerbate these conditions by affecting hormone transport or metabolism. Proper understanding of thyroxine's mechanisms and pathways informs effective treatment and management of these thyroid disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850124251305,"sku":"ab30833","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab30833","provider":"Iright","version":"1.0","type":"link"}