{"product_id":"abcam-ab308519","title":"Abcam, ab308519, Anti-HOXC10 antibody [EPR27318-83] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal HOXC10 antibody. Carrier free. Suitable for WB, ICC\/IF, Flow Cyt (Intra) and reacts with Transfected cell lysate - Human, Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27318-83,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHOXC10 also known as Homeobox C10 is a transcription factor that plays an important role in the regulation of gene expression. This protein weighing approximately 37 kDa belongs to the homeobox family and is involved in morphogenesis specifically in the development of the limbs and axial skeleton. Researchers have identified its expression in various tissues including the central nervous system and skeletal muscle. The presence of HOXC10 in these areas suggests its involvement in complex developmental processes and its importance in proper structural formation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nHOXC10 participates in regulating cell differentiation and proliferation. It acts as a transcriptional regulator and part of the homeobox gene family which functions in determining cell fate and positional development. This factor does not function alone; it forms complexes with other proteins to exert its effects on target genes. By regulating the expression of other genes it supports the establishment of specific cellular phenotypes necessary for proper tissue and organ development.\u003cbr\u003e\nPathways\u003cbr\u003e\nHOXC10 interacts with multiple signaling pathways including the Wnt and Hedgehog pathways which are critical for development and growth. In the Wnt pathway HOXC10 collaborates with other homeobox genes to influence gene expression necessary for proper cell positioning. It also relates closely with other HOX proteins such as HOXA1 and HOXD10 coordinating complex regulation processes that guide embryonic development and patterning.\u003cbr\u003e\nHOXC10 has connections to several pathological conditions including cancers and neurological disorders. Aberrant expression of HOXC10 has been linked with breast cancer where it is believed to promote cancer cell proliferation and survival. Additionally changes in HOXC10 expression are associated with developmental disorders involving skeletal and neural defects. Proteins like HOXB7 and HOXD13 interact with HOXC10 showing their involvement in the regulation of pathways that when disrupted may lead to disease states. Understanding its role better could offer insights into targeted therapies for these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851872194729,"sku":"ab308519","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab308519","provider":"Iright","version":"1.0","type":"link"}