{"product_id":"abcam-ab309146","title":"Abcam, ab309146, Anti-FBXO38 antibody [EPR27363-29] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal FBXO38 antibody. Carrier free. Suitable for WB and reacts with Human, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27363-29,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFBXO38 also known as FBX5 is a member of the F-box protein family which plays a significant role in protein ubiquitination. This process marks proteins for degradation by the ubiquitin-proteasome system an important step for maintaining cellular protein balance. FBXO38 weighs approximately 60 kDa and is part of the SCF (SKP1-CUL1-F-box) complex. This protein is expressed in various tissues with higher levels observed in muscle tissues and some parts of the central nervous system.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nFBXO38 participates in regulating protein stability and turnover as an integral component of the ubiquitin-proteasome system. As part of the SCF complex FBXO38 works in collaboration with SKP1 CUL1 and other F-box proteins to select target proteins for ubiquitination. Its role in this complex positions it as a critical regulator of cell cycle progression apoptosis and signal transduction pathways. By selecting specific proteins for degradation FBXO38 influences key cellular functions and ensures proper cellular responses to environmental changes.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe function of FBXO38 aligns with the regulation of the MAPK\/ERK pathway and the NF-kB pathway. These pathways are essential for cell proliferation survival and inflammation responses. In the MAPK\/ERK pathway FBXO38 interacts with components to ensure timely degradation of key signaling proteins thereby modulating pathway activity. Furthermore FBXO38’s interaction with proteins like IκBα in the NF-kB pathway helps control the transcriptional activity of NF-kB influencing immunological and stress responses.\u003cbr\u003e\nAltered FBXO38 function has connections to muscular atrophy and certain cancers. Variations or mutations in FBXO38 can lead to disruptions in muscle cell protein turnover contributing to muscle-wasting disorders. Additionally improper FBXO38 activity can affect proteins such as MDM2 in oncogenic pathways influencing cancer development and progression. These associations make FBXO38 a potential therapeutic target for addressing protein dysregulation-related diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852463526057,"sku":"ab309146","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab309146","provider":"Iright","version":"1.0","type":"link"}