{"product_id":"abcam-ab309473","title":"Abcam, ab309473, Anti-SCN3A antibody [EPR25135-66]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal SCN3A antibody. Suitable for WB and reacts with Transfected cell lysate - Human, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR25135-66,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Rat,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSCN3A also known as sodium channel voltage-gated type III alpha subunit or NaV1.3 plays a mechanical role in the conduction of electrical signals in excitable cells. It forms part of the voltage-gated sodium channels that are critical in the generation and propagation of action potentials. SCN3A has a molecular mass of approximately 260 kDa and is expressed broadly in the central nervous system particularly in neurons.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe voltage-gated sodium channel SCN3A contributes to rapid depolarization in neuronal action potentials. It is an important component of a larger sodium channel complex which includes beta subunits that regulate the kinetic properties and localization of these channels. This enables proper neuronal signaling and communication affecting processes such as neurotransmission and response to stimuli.\u003cbr\u003e\nPathways\u003cbr\u003e\nSCN3A influences the regulation of neuronal excitability and synaptic activity. It operates within the action potential pathway and has connections to the calcium signaling pathway which impacts numerous cellular processes. SCN3A functions alongside proteins such as SCN1A and SCN2A within these pathways contributing to the integrated organization of electrical signaling in neurons.\u003cbr\u003e\nMutations or dysregulations in SCN3A relate to epilepsy and neurodevelopmental disorders. SCN3A's interaction with SCN1A is significant as alterations in sodium channel function can lead to imbalance in neuronal excitability and seizures. These relationships highlight the importance of SCN3A in maintaining normal neural function and its potential as a therapeutic target in related neurologic conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850226880681,"sku":"ab309473","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab309473","provider":"Iright","version":"1.0","type":"link"}