{"product_id":"abcam-ab313522","title":"Abcam, ab313522, Human Cathepsin E ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nHuman Cathepsin E ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human Cathepsin E in Human in Cell Culture Media, Biofluids samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Cell culture supernatant, Serum,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:= 14.5 pg\/mL,\u003cbr\u003e\nRange:14.5 - 4000 pg\/mL,\u003cbr\u003e\nAssay Platform:Pre-coated microplate (12 x 8 well strips)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nHuman Cathepsin E ELISA kit is an\u003cbr\u003e\nin vitro\u003cbr\u003e\nenzyme-linked immunosorbent assay for the quantitative measurement of human Cathepsin E in serum (plasma is not recommended in this assay) and cell culture supernatants. This assay employs an antibody specific for human Cathepsin E coated on a 96-well plate.\u003cbr\u003e\nThis ELISA kit shows no cross-reactivity with the following cytokines tested: human B7-2 (CD86); BAFF R (TNFRSF13C); Calcitonin; Calsyntenin-1; cIAP-2 (HIAP-1); Coagulation Factor VII; Complement MASP3; Endocan; EphA2; EphB4; Ephrin-A4; FGF-23; FGF-5; Flt-3 (Flk-2); GLP-1 (7-37 \u0026amp; 7-36- NH2); Glypican 2; GM-CSF R alpha; GP73 (GOLM1); HTRA2 (Omi); IL-20 R alpha; IL-4 R alpha; JAM-C; Luteinizing Hormone (LH); Matrilin-3; Meprin alpha (MEP1A); MSP R (Ron); N-Cadherin; Neprilysin-2 (MMEL1); NKp44; Pappalysin-1 (PAPP-A); Parathyroid hormone (PTH); Pepsinogen II (PGC); Peptide YY (PYY); Presenilin 1 (PSEN1); SOX2; TFPI-2; TRACP (ACP5); Trefoil factor 3 (TFF3); Ubiquitin+1.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCathepsin E also known as CATE is an aspartic protease with a molecular mass of approximately 40 kDa. It functions within the cell to perform endopeptidase activity meaning it cleaves peptide bonds within proteins. Cathepsin E shows expression in the gastric mucosa and is prevalent in immune-related tissues such as the spleen and thymus. This enzyme operates optimally at acidic pH levels specializing in the breakdown of proteins in lysosomes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCathepsin E plays a role in protein degradation and processing within lysosomal compartments. It associates with lysosomal and endosomal pathways participating actively in immune response regulation. Cathepsin E does not form part of a larger complex; however its activity can influence the function of other immune-related proteins by modifying antigen presentation.\u003cbr\u003e\nPathways\u003cbr\u003e\nCathepsin E engages with the major histocompatibility complex (MHC) class II pathway. This involvement assists in the processing of antigenic peptides for presentation to CD4+ T-cells connecting Cathepsin E to adaptive immune responses. Additionally it interacts with proteins such as HLA-DM which modulates the peptide loading on MHC class II molecules during immune surveillance.\u003cbr\u003e\nResearchers link Cathepsin E to gastric cancer and Alzheimer's disease. In gastric cancer Cathepsin E overexpression can alter tumor microenvironments impacting disease progression. Furthermore in Alzheimer's disease Cathepsin E's activity correlates with amyloid precursor protein (APP) metabolism which can influence the accumulation of amyloid-beta plaques a hallmark of the disease process.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843769651369,"sku":"ab313522","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab313522","provider":"Iright","version":"1.0","type":"link"}