{"product_id":"abcam-ab313612","title":"Abcam, ab313612, Anti-LILRB5 antibody [EPR23896-84]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal LILRB5 antibody. Suitable for WB, Flow Cyt (Intra), ICC\/IF and reacts with Human, Transfected cell lysate - Human, Transfected cell line - Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR23896-84,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe LILRB5 protein also known as Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 5 has an approximate mass of 65 kDa. It belongs to the immunoglobulin superfamily and is primarily found on the surface of several immune cells including monocytes and macrophages. LILRB5 plays a significant role in down-modulating immune responses by interacting with its ligands.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein functions as an inhibitory receptor that modulates immune cell activation and responses. It is not part of a larger protein complex but works individually to regulate anti-inflammatory signaling pathways. Its activity helps maintain immune homeostasis and prevents overactivation of immune responses which can lead to tissue damage.\u003cbr\u003e\nPathways\u003cbr\u003e\nLILRB5 acts within the context of immune response regulation. It is involved in pathways related to immunosuppressive signaling notably the PD-1 receptor pathway. LILRB5 interacts with other immune-regulating proteins like LILRB1 and PD-L1 which coordinate to control immune checkpoint signaling suppressing excessive immune reactions.\u003cbr\u003e\nLILRB5 has connections to autoimmune diseases and cancer. Its role in suppressing immune responses links it to autoimmune conditions where inappropriate targeting of self-tissues occurs suggesting that its dysregulation may lead to such disorders. Furthermore in cancer tumor cells might exploit LILRB5-mediated pathways to evade immune surveillance. Related proteins like LILRB1 and PD-L1 further complicate these pathways influencing disease progression and therapeutic outcomes.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850422833321,"sku":"ab313612","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab313612","provider":"Iright","version":"1.0","type":"link"}