{"product_id":"abcam-ab313627","title":"Abcam, ab313627, Anti-UVRAG antibody [EPR27025-83] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal UVRAG antibody. Carrier free. Suitable for WB and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27025-83,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab313627 is the carrier-free version of\u003cbr\u003e\nab313626\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nUVRAG also known as UV radiation resistance-associated gene is a protein with a molecular weight of approximately 70 kDa. This protein exists within various tissues but shows higher expression in the brain heart and skeletal muscle. The mechanistic role of UVRAG involves its interaction with cellular membranes mediating autophagy and endocytic trafficking processes which are essential for cellular homeostasis and defense against stress.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nUVRAG regulates important cellular processes contributing to autophagy by promoting the maturation of autophagosomes into lysosomes. It is an integral part of the PI3K complex working alongside other proteins such as Beclin 1. Through these interactions UVRAG aids cell survival under nutrient-deficient conditions by facilitating the degradation of damaged organelles and protein recycling.\u003cbr\u003e\nPathways\u003cbr\u003e\nUVRAG's role extends to its involvement in the mTOR signaling pathway and the endocytic pathway. Within the mTOR pathway UVRAG interacts with proteins like Rubicon and Beclin 1 acting as a modulator of cellular growth and response to energy status. In the endocytic pathway UVRAG collaborates with the VPS34 complex influencing the sorting and degradation of cellular cargo. These pathways highlight UVRAG's importance in cellular metabolism and regulation.\u003cbr\u003e\nUVRAG shows significant connections particularly in cancer and neurodegenerative diseases. Mutations or altered expressions of UVRAG can contribute to tumorigenesis by disrupting autophagic balance or fail in cell death processes. In cancer UVRAG interacts with proteins such as p53 influencing tumor suppressor activities. In neurodegenerative disorders its regulatory role in autophagy becomes impaired contributing to protein aggregation and cell death highlighting UVRAG as a potential therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852342546601,"sku":"ab313627","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab313627","provider":"Iright","version":"1.0","type":"link"}