{"product_id":"abcam-ab313687","title":"Abcam, ab313687, Human DSCAML1 ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nHuman DSCAML1 ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human DSCAML1 in Human in Cell Culture Media, Biofluids samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Cell culture supernatant, Plasma, Serum,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:= 0.82 ng\/mL,\u003cbr\u003e\nRange:0.82 - 200 ng\/mL,\u003cbr\u003e\nAssay Platform:Pre-coated microplate (12 x 8 well strips)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nHuman DSCAML1 ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human DSCAML1 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human DSCAML1 coated on a 96-well plate.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe protein DSCAML1 also known as Down syndrome cell adhesion molecule-like 1 plays a mechanical role in cell adhesion and signaling. This protein with a mass of approximately 220 kDa belongs to the immunoglobulin superfamily. DSCAML1 is expressed in various tissues most notably in the nervous system where it helps in the development of neural circuits. The target is known for its complex structure which allows it to mediate homophilic cell-cell interactions essential for neuronal positioning and axonal pathfinding.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nDSCAML1 is involved in neural patterning and synaptic connectivity. The protein contributes to neural migration processes during development ensuring proper brain morphogenesis. Research suggests that DSCAML1 forms part of a molecular complex that aids in axon guidance important for network formation within the brain. Together with other cell adhesion molecules DSCAML1 influences synapse formation and stability impacting neural networks' functional integrity.\u003cbr\u003e\nPathways\u003cbr\u003e\nDSCAML1 participates in signaling pathways critical for nervous system development. It significantly influences axon guidance and synaptic signaling pathways. DSCAML1 interacts with other proteins like DSCAM and DCC (Deleted in Colorectal Cancer) which are known to play roles in cellular communication and neuronal growth processes. These interactions contribute to the proteins' collective ability to orchestrate developmental and functional aspects of the central nervous system.\u003cbr\u003e\nDSCAML1 mutations have associations with neurodevelopmental disorders such as autism spectrum disorders and intellectual disabilities. Alterations in DSCAML1 functions may disrupt neural circuitry leading to these conditions. Proteins like DSCAM whose gene duplication or mutations often occur in Down syndrome share pathways or functions with DSCAML1 and disruptions in these interactions stand linked to altered neural development and related cognitive concerns.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843759919273,"sku":"ab313687","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab313687","provider":"Iright","version":"1.0","type":"link"}