{"product_id":"abcam-ab313761","title":"Abcam, ab313761, Anti-TrkC antibody [EPR22959-404]","description":"\u003cp\u003eSize: 10µL-TRIAL \/ 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal TrkC antibody. Suitable for WB, IP and reacts with Human, Mouse, Rat, Transfected cell lysate - Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR22959-404,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTrkC also known as neurotrophic receptor tyrosine kinase 3 (NTRK3) is a receptor protein encoded by the NTRK3 gene. It weighs approximately 85 kDa and is expressed in the central and peripheral nervous systems as well as in several non-neuronal tissues. TrkC is a member of the TRK family of tyrosine kinase receptors which includes TrkA and TrkB. As a receptor TrkC binds to neurotrophin-3 (NT-3) to initiate signal transduction processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTrkC is critical for neuronal development and function. It is part of a signaling complex that mediates the effects of the neurotrophin-3 involved in the survival differentiation and maintenance of various neuron populations. TrkC activation leads to the phosphorylation of the receptor and downstream signaling molecules impacting cellular outcomes. It has important roles in nervous system development and in processes such as synaptic plasticity and memory formation.\u003cbr\u003e\nPathways\u003cbr\u003e\nTrkC participates in neurotrophin signaling and MAPK pathways. These pathways regulate important cellular activities like growth survival and differentiation. In the context of neurotrophin signaling related proteins such as TrkA and TrkB share similar pathway components influencing similar biological processes. TrkC plays a pivotal role in modulating pathway-related cellular responses and integrating signals from NT-3 to execute proper neuronal functioning.\u003cbr\u003e\nTrkC links to various neurological conditions including neurodevelopmental and mood disorders. Dysregulation or mutations in TrkC can lead to diseases such as medulloblastoma and congenital insensitivity to pain with anhidrosis (CIPA). The connection to NT-3 is significant in these conditions as disrupted TrkC\/NT-3 signaling affects neuronal survival and development contributing to disease pathogenesis. The targeting of TrkC-related pathways holds potential for therapeutic interventions targeting these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850353627305,"sku":"ab313761","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab313761","provider":"Iright","version":"1.0","type":"link"}