{"product_id":"abcam-ab313887","title":"Abcam, ab313887, Anti-Influenza A virus PB1 antibody [EPR28248-26]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal RDRP antibody. Suitable for I-ELISA, WB, IHC-P, ICC\/IF, Flow Cyt (Intra) and reacts with Recombinant fragment - Influenza A, Transfected cell lysate - Influenza A, Transfected cell line - Influenza A samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28248-26,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Influenza A,\u003cbr\u003e\nApplications:Flow Cyt (Intra), ICC\/IF, IHC-P, I-ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Influenza A virus PB1 protein also known as Polymerase basic protein 1 is an important component of the influenza virus polymerase complex. It has an approximate mass of 87 kDa and is primarily expressed in infected host cells. This protein facilitates the synthesis of viral RNA by utilizing the viral ribonucleoprotein (vRNP) complex. PB1's main mechanical function is its role in RNA-dependent RNA polymerase activity which is critical for the replication of the influenza viral genome.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe PB1 protein collaborates with two other polymerase proteins PB2 and PA in the formation of the influenza virus RNA polymerase complex. This complex is essential for catalyzing the transcription and replication of the virus's segmented negative-strand RNA genome within the host cell. The polymerase activity of PB1 drives the production of viral RNA ensuring the assembly of new viral particles for subsequent cycles of infection.\u003cbr\u003e\nPathways\u003cbr\u003e\nPB1 protein functions centrally in the viral replication and transcription pathways within infected host cells. It interacts with PB2 and PA proteins to align with these pathways facilitating genomic replication and transcription of viral mRNA. The role of PB1 in catalyzing RNA synthesis also connects it to the host's cellular machinery pathways exploiting components such as the cellular nuclear export pathway to ensure efficient viral genome replication and viral propagation.\u003cbr\u003e\nPB1 is closely linked to the pathogenesis of influenza an acute respiratory illness. This association drives the virus's ability to cause widespread outbreaks and pandemics. The PB1 protein works in conjunction with HA (hemagglutinin) and NA (neuraminidase) proteins to infect and propagate in the host contributing to disease severity. Efforts to understand PB1's interaction with the host cell immune response continue as this knowledge aids in developing antiviral strategies against influenza infections.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850364670121,"sku":"ab313887","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/ar\/products\/abcam-ab313887","provider":"Iright","version":"1.0","type":"link"}